Evaluation of the anti-stress effects of five Tunisian aromatic and medicinal plants in vitro

被引：4
作者：
Ben Othman, Mahmoud [1 ]
Neffati, Mohamed [2 ]
Isoda, Hiroko [1 ,3 ]
机构：
[1] Univ Tsukuba, Alliance Res Mediterranean & North Africa AREMNA, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058572, Japan
[2] Arid Land Inst, Range Ecol Lab, Medenine 4119, Tunisia
[3] Univ Tsukuba, Fac Life & Environm Sci, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058572, Japan
来源：
JOURNAL OF HERBAL MEDICINE | 2021年 / 27卷
关键词：
Medicinal plants; Anti-stress; Heat shock; Acetylcholine; Heat shock proteins; HEAT-SHOCK PROTEINS; STRESS GENERATION; ANTIOXIDANT; EXTRACTS; L; POLYPHENOLS; GLUTATHIONE; ANTICANCER; CHAPERONES; MODULATORS;
D O I：
10.1016/j.hermed.2018.10.003
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
The present study was designed to evaluate the anti-stress effects of the ethanol extracts of five medicinal plants from Southern part of Tunisia, traditionally used in folk medicine: Cymbopogon schoenanthus Spreng. (CSEE), Crithmum maritimum L. (CMEE), Arthrophytum scoparium (Pomel) ll?jin (ASEE), Artemisia herba-alba Asso. (AHEE), and Rhanterium suaveolens Desf. (RSEE). Assays using SH-SY5Y cells and HSP47-transformed CHO cells (HSP47+/ - cells) were performed. Heat (at 42 ?C, for 90 min) was used to induce stress in pre-treated cells. The tested plants at 1/1000 dilution significantly enhanced the reversal of the heat shock protein expression in heat-stressed HSP47+/- cells as shown by the enhanced expression of heat shock proteins HSP27, HSP70 and HSP90 mRNAs in heat-treated SH-SY5Y cells. Moreover, CSEE at 1/1000 and 1/100 (v/v) dilutions showed no cytotoxic effects on both SH-SY5Y and HSP47-/+ cells. In addition, the results demonstrated that CSEE and RSEE promoted the recovery of acetylcholine (Ach) compared to heat-stressed SH-SY5Y cells. These results suggest that C. schoenanthus, C. maritimum, and R. suaveolens can modulate stress, and a follow up study on the bioactivities of these species may offer a new source of phytomedicines for the effective treatment of stress-related diseases.
引用
收藏
页数：7
相关论文
共 50 条
[1]  
[Anonymous], 1954, FLORE ANAL SYNOPTIQU
[2]   Hsp27 consolidates intracellular redox homeostasis by upholding glutathione in its reduced form and by decreasing iron intracellular levels [J].
Arrigo, AP ;
Virot, S ;
Chaufour, S ;
Firdaus, W ;
Kretz-Remy, C ;
Diaz-Latoud, C .
ANTIOXIDANTS & REDOX SIGNALING, 2005, 7 (3-4) :414-424
[3]  
Atia A, 2011, J MED PLANTS RES, V5, P3564
[4]   Enhanced antioxidant effect of caffeic acid phenethyl ester and Trolox in combination against radiation induced-oxidative stress [J].
Bai, Hua ;
Liu, Rui ;
Chen, Hong-Li ;
Zhang, Wei ;
Wang, Xin ;
Zhang, Xiao-Di ;
Li, Wen-Li ;
Hai, Chun-Xu .
CHEMICO-BIOLOGICAL INTERACTIONS, 2014, 207 :7-15
[5]   'The stress of ding': the role of heat shock proteins in the regulation of apoptosis [J].
Beere, HM .
JOURNAL OF CELL SCIENCE, 2004, 117 (13) :2641-2651
[6]   Antistress Effects of the Ethanolic Extract from Cymbopogon schoenanthus Growing Wild in Tunisia [J].
Ben Othman, Mahmoud ;
Han, Junkyu ;
El Omri, Abdelfatteh ;
Ksouri, Riadh ;
Neffati, Mohamed ;
Isoda, Hiroko .
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2013, 2013
[7]  
Bianco V.V., 2009, PIANTE SPONTANEE NEL, P111
[8]   Targeting chaperones, heat shock factor-1, and unfolded protein response: Promising therapeutic approaches for neurodegenerative disorders [J].
Bose, Shambhunath ;
Cho, Jungsook .
AGEING RESEARCH REVIEWS, 2017, 35 :155-175
[9]  
Bouaziz M, 2009, AFR J BIOTECHNOL, V8, P7017
[10]   Antioxidant activities of eight Algerian plant extracts and two essential oils [J].
Boulanouar, Bakchiche ;
Abdelaziz, Gherib ;
Aazza, Smail ;
Gago, Custodia ;
Graca Miguel, M. .
INDUSTRIAL CROPS AND PRODUCTS, 2013, 46 :85-96
12345