With the Help of MOM: Mitochondrial Contributions to Cellular Quality Control

被引：24

作者：

Braun, Ralf J. ^{[1
]}

Westermann, Benedikt ^{[1
]}

机构：

[1] Univ Bayreuth, Inst Zellbiol, Univ Str 30, D-95440 Bayreuth, Germany

来源：

TRENDS IN CELL BIOLOGY | 2017年 / 27卷 / 06期

关键词：

UBIQUITIN-PROTEASOME SYSTEM; INTERMEMBRANE SPACE PROTEINS; TAIL-ANCHORED PROTEINS; SACCHAROMYCES-CEREVISIAE; DAMAGED MITOCHONDRIA; MISFOLDED PROTEINS; DEGRADATION; PARKIN; YEAST; MITOPHAGY;

D O I：

10.1016/j.tcb.2017.02.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mitochondria are essential organelles because they have key roles in cellular energy metabolism and many other metabolic pathways. Several quality control systems have evolved to ensure that dysfunctional mitochondria are either repaired or eliminated. The activities of these pathways are crucial for cellular health because they maintain functional mitochondria. In addition, the cytosolic ubiquitin-proteasome system (UPS) and the mitochondria-associated degradation pathway (MAD) share some of their core components, are functionally tightly interconnected, and mutually modulate their activities. Thus, the mitochondrial outer membrane (MOM) actively supports quality control systems in extramitochondrial compartments. Furthermore, mitochondrial quality surveillance systems also act on cytosolic or endoplasmic reticulum (ER) substrates and modulate immune responses. Therefore, mitochondria contribute to cellular quality control and homeostasis on several levels.

引用

页码：441 / 452

页数：12

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