The mu-opioid receptor is necessary for [D-Pen(2),D-Pen(5)]enkephalin-induced analgesia

被引：98
|
作者：
Sora, I
Funada, M
Uhl, GR
机构：
[1] NIDA,MOL NEUROBIOL BRANCH,IRP,BALTIMORE,MD 21224
[2] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL,BALTIMORE,MD 21205
[3] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21205
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1997年 / 324卷 / 2-3期
关键词：
DPDPE; ([D-Pen(2); D-Pen(5)]enkephalin); delta-opioid receptor; mu-opioid receptor knockout mouse;
D O I：
10.1016/S0014-2999(97)10016-4
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Interactions between delta-opioid receptors and morphine preferring mu-opioid receptor subtypes have been suggested. Availability of transgenic mu-opioid receptor knockout mice allows assessment of mu-opioid receptor roles in the analgesia produced by the classical delta-opioid receptor agonist [D-Pen(2),D-Pen(5)]enkephalin (DPDPE) in hot-plate and tail-flick tests. DPDPE analgesia was dramatically reduced in mu-opioid receptor knockout mice in a gene-dose-dependent fashion. The analgesia induced by this classic delta-opioid receptor agonist depends on intact mu-opioid receptors, suggesting that selective delta-opioid receptor drugs may require mu-opioid receptor occupancies for full efficacy.
引用
收藏
页码：R1 / R2
页数：2
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