Synthesis, Characterization and Application of β-Cyclodextrin/Imidazolium Based Dicationic Ionic Liquid Supported on Silica Gel as a Novel Catalyst in Hantzsch Condensation Reaction

Regarding the green chemistry's goals, ionic liquids (ILs) open a way to introduce amazing and efficient media for different reactions. Therefore, in the present study, a feasible protocol for the preparation of beta-cyclodextrin/imidazolium based dicationic ionic liquid and its supported on silica gel, [beta CD/Im](OTs)(2)-Silica are presented. Ability of this eco-friendly microvessel and host ionic liquid system in the one-pot three-components Hantzsch condensation reaction of arylaldehydes, ethylacetoacetate or dimedone and ammonium acetate are also described. The mild and easy reaction conditions, utilization of a catalyst with high catalytic activity and good reusability, and simple work-up procedure, makes this method as an interesting option for the facile and efficient synthesis of 1,4-dihydropyridine and polyhydroquinoline derivatives.