Unscheduled apoptosis during acute inflammatory lung injury

被引:42
作者
Mantell, LL
Kazzaz, JA
Xu, J
Palaia, TA
Piedboeuf, B
Hall, S
Rhodes, GC
Niu, G
Fein, AF
Horowitz, S
机构
[1] SUNY STONY BROOK,WINTHROP UNIV HOSP,SCH MED,CARDIOPULM RES INST,DEPT MED PULM & CRIT CARE,MINEOLA,NY 11501
[2] SUNY STONY BROOK,WINTHROP UNIV HOSP,SCH MED,DEPT MED NEPHROL,MINEOLA,NY 11501
[3] UNIV LAVAL,CHUL,CTR RECH,DEPT PEDIAT NEONATOL,ST FOY,PQ G1V 4G2,CANADA
[4] OREGON HLTH SCI UNIV,PORTLAND,OR 97201
[5] BARRATT & SMITH PATHOL,ORANGE,NSW 2800,AUSTRALIA
关键词
programmed cell death; necrosis; hyperoxia; oleic acid;
D O I
10.1038/sj.cdd.4400278
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Apoptosis is a mode of cell death currently thought to occur in the absence of inflammation, In contrast, inflammation follows unscheduled events such as acute tissue injury which results in necrosis, not apoptosis, We examined the relevance of this paradigm in three distinct models of acute lung injury; hyperoxia, oleic acid, and bacterial pneumonia. In every case, it was found that apoptosis is actually a prominent component of the acute and inflammatory phase of injury, Moreover, using strains of mice that are differentially sensitive to hyperoxic lung injury we observed that the percent of apoptotic cells was well correlated with the severity of lung injury, These observations suggest that apoptosis may be one of the biological consequences during acute injury and the failure to remove these apoptotic cells may also contribute to the inflammatory response.
引用
收藏
页码:600 / 607
页数:8
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