The time course of drug effects

被引：15

作者：

Al-Sallami, Hesham S. ^{[1
]}

Kumar, Venkata V. Pavan ^{[1
]}

Landersdorfer, Cornelia B. ^{[2
]}

Bulitta, Jurgen B. ^{[2
]}

Duffull, Stephen B. ^{[1
]}

机构：

[1] Univ Otago, Sch Pharm, Dunedin, New Zealand

[2] SUNY Buffalo, Buffalo, NY 14260 USA

来源：

PHARMACEUTICAL STATISTICS | 2009年 / 8卷 / 03期

关键词：

pharmacokinetics; pharmacodynamics; pharmacometrics; 4 BASIC MODELS; PHARMACOKINETICS; PHARMACODYNAMICS; KINETICS;

D O I：

10.1002/pst.393

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This review aims to introduce the concepts and principles underpinning the time course of drug effects. Models describing the time course of drug concentrations (pharmacokinetic models) and the ensuing concentration-effect (pharmacodynamics models) as well as the linked time-effect (pharmacokinetic-pharmacodynamic models) are introduced. Different types of drug time-effects models are discussed with examples which aim to explain the time course of onset, duration, and maximal effect that occurs from any given dosing schedule. These drug effects are also described in relation to disease progression models. Copyright (C) 2009 John Wiley & Sons, Ltd.

引用

页码：176 / 185

页数：10

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