Liposome-Containing Mechanoresponsive Hydrogels

被引:16
|
作者
Stalder, E. [1 ,2 ]
Zumbuehl, A. [1 ,2 ]
机构
[1] Univ Fribourg, Dept Chem, Swiss Natl Ctr Competence Res Chem Biol Geneva, Chemin Musee 9, CH-1700 Fribourg, Switzerland
[2] Univ Fribourg, Dept Chem, Swiss Natl Ctr Competence Res Bioinspired Mat Fri, Chemin Musee 9, CH-1700 Fribourg, Switzerland
基金
瑞士国家科学基金会;
关键词
arthritis; hydrogels; liposomes; mechanoresponsive drug delivery; on demand drug delivery; CATANIONIC VESICLES; DRUG-DELIVERY; RELEASE; CHITOSAN; PREVALENCE; ARTHRITIS;
D O I
10.1002/mame.201600549
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
The direct injection of a drug into a joint can relieve osteoarthritic pain for a short period of time. The problem is that the drug will not stay at the allocated location. Therefore, a proof-of-concept in situ is designed forming hydrogel containing liposomes that are covalently linked to the hydrogel network. When the liposomes are filled with a cargo, the formed hydrogel is thus loaded with this cargo, too. Due to the link between the hydrogel and the liposomes, a compression or other mechanical force applied to the hydrogel will rupture the liposomes and release a small percentage of the cargo. Overall, a long-term intra-articular drug release is feasible.
引用
收藏
页数:6
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