Reversible Mild Cognitive Impairment: The Role of Comorbidities at Baseline Evaluation

被引:33
作者
Grande, Giulia [1 ]
Cucumo, Valentina [1 ]
Cova, Ilaria [1 ]
Ghiretti, Roberta [1 ]
Maggiore, Laura [1 ]
Lacorte, Eleonora [2 ]
Galimberti, Daniela [3 ]
Scarpini, Elio [3 ]
Clerici, Francesca [1 ]
Pomati, Simone [1 ]
Vanacore, Nicola [2 ]
Mariani, Claudio [1 ]
机构
[1] Univ Milan, Ctr Res & Treatment Cognit Dysfunct, Biomed & Clin Sci Dept, Luigi Sacco Hosp, I-20157 Milan, Italy
[2] Natl Inst Hlth, Natl Ctr Epidemiol, Rome, Italy
[3] Univ Milan, Dept Pathophysiol & Transplantat, Fdn Ca Granda, IRCCS Osped Policlin, I-20157 Milan, Italy
关键词
Comorbidity; dementia; mild cognitive impairment; prevention; MINI-MENTAL-STATE; DIAGNOSTIC-CRITERIA; ALZHEIMERS-DISEASE; NORMATIVE VALUES; DEMENTIA; DECLINE; PROGRESSION; DEPRESSION; CONSENSUS; SYMPTOMS;
D O I
10.3233/JAD-150786
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The prognostic value of mild cognitive impairment (MCI) is being questioned, with some MCI subjects reverting to normal cognition (NC). The reversion rate varies mostly depending on the study design, the setting, and both MCI and NC definitions. Previous studies have focused on the profile of subjects who revert to NC, but the role of comorbidities has not been entirely investigated. We aimed to evaluate the proportion of MCI subjects who revert to NC in a memory clinic context, focusing on the role of comorbidities. Between 2004 and 2013, 374 MCI subjects were recruited. During a mean time of 32 +/- 25.5 months, 21 subjects (5.6%) reverted to NC. Subjects who reverted to NC were younger (p = 0.0001), more educated (p = 0.0001), had a better global cognition (p = 0.0001), as assessed by the Mini-Mental State Examination (MMSE) and suffered from more comorbidities (p = 0.002), as assessed by Cumulative Illness Rating Scale (CIRS) than those who developed dementia. The Cox Regression Model, constructed to adjust for the confounders, showed that the higher were the MMSE (HR = 1.83, CI 95%: 1.07-3.11) and the CIRS score (HR = 1.3, CI 95% 0.88-1.92) at baseline, the higher was the probability of returning to NC than developing dementia, though the last association was not significant. Subjects who reverted to NC were more frequently affected by respiratory (p = 0.002), urologic (p = 0.012), and psychiatric (p = 0.012) diseases. The cognitive performance of subjects with medical comorbidities could benefit from preventive strategies aimed at treating the underlying diseases.
引用
收藏
页码:57 / 67
页数:11
相关论文
共 54 条
  • [1] [Anonymous], 1994, DSM 4
  • [2] [Anonymous], 2012, SPSS Statistics for Windows
  • [3] The Frontal Assessment Battery (FAB): Normative values in an Italian population sample
    Appollonio, I
    Leone, M
    Isella, V
    Piamarta, F
    Consoli, T
    Villa, ML
    Forapani, E
    Russo, A
    Nichelli, P
    [J]. NEUROLOGICAL SCIENCES, 2005, 26 (02) : 108 - 116
  • [4] On Which Abilities Are Category Fluency and Letter Fluency Grounded? A Confirmatory Factor Analysis of 53 Alzheimer's Dementia Patients
    Bizzozero, Ilaria
    Scotti, Stefania
    Clerici, Francesca
    Pomati, Simone
    Laiacona, Marcella
    Capitani, Erminio
    [J]. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA, 2013, 3 (01): : 179 - 191
  • [5] Rey-Osterrieth complex figure: normative values in an Italian population sample
    Caffarra, P
    Vezzadini, G
    Dieci, F
    Zonato, F
    Venneri, A
    [J]. NEUROLOGICAL SCIENCES, 2002, 22 (06) : 443 - 447
  • [6] Caffarra P., 2002, Nuova Riv. Neurol, V12, P111
  • [7] Composite neuropsychological batteries and demographic correction: Standardization based on Equivalent Scores, with a review of published data
    Capitani, E
    Laiacona, M
    [J]. JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY, 1997, 19 (06) : 795 - 809
  • [8] The mental deterioration battery: Normative data, diagnostic reliability and qualitative analyses of cognitive impairment
    Carlesimo, GA
    Caltagirone, C
    Gainotti, G
    Fadda, L
    Gallassi, R
    Lorusso, S
    Marfia, G
    Marra, C
    Nocentini, U
    Parnetti, L
    [J]. EUROPEAN NEUROLOGY, 1996, 36 (06) : 378 - 384
  • [9] Modifiable Predictors of Dementia in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis
    Cooper, Claudia
    Sommerlad, Andrew
    Lyketsos, Constantine G.
    Livingston, Gill
    [J]. AMERICAN JOURNAL OF PSYCHIATRY, 2015, 172 (04) : 323 - 334
  • [10] Age-Associated Memory Impairment: Proposed Diagnostic Criteria and Measures of Clinical Change - Report of a National Institute of Mental Health Work Group
    Crook, Thomas
    Bartus, Raymond T.
    Ferris, Steven H.
    Whitehouse, Peter
    Cohen, Gene D.
    Gershon, Samuel
    [J]. DEVELOPMENTAL NEUROPSYCHOLOGY, 1986, 2 (04) : 261 - 276