PDGF-C is a new protease-activated ligand for the PDGF α-receptor

被引：489

作者：

Li, XR

Pontén, A

Aase, K

Karlsson, L

Abramsson, A

Uutela, M

Bäckström, G

Hellström, M

Boström, H

Li, H

Soriano, P

Betscholtz, C

Heldin, CH

Alitalo, K

Östman, A

Eriksson, U

机构：

[1] Ludwig Inst Canc Res, Stockholm Branch, S-17177 Stockholm, Sweden

[2] Gothenburg Univ, Dept Med Biochem, S-41390 Gothenburg, Sweden

[3] Univ Helsinki, Haartman Inst, Mol Canc Biol Lab, SF-00014 Helsinki, Finland

[4] Ludwig Inst Canc Res, Uppsala Branch, S-75124 Uppsala, Sweden

[5] Fred Hutchinson Canc Res Ctr, Program Dev Biol, Div Basic Sci, Seattle, WA 98109 USA

来源：

NATURE CELL BIOLOGY | 2000年 / 2卷 / 05期

关键词：

D O I：

10.1038/35010579

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Platelet-derived growth factors (PDGFs) are important in many types of mesenchymal cell. Here we identify a new PDGF, PDGF-C, which binds to and activates the PDGF alpha-receptor. PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. In situ hybridization analysis In the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion. Analysis of kidneys lacking the PDGF alpha-receptor shows selective loss of mesenchymal cells adjacent to sites of expression of PDGF-C mRNA; this is not found in kidneys from animals lacking PDGF-A or both PDGF-A and PDGF-B, indicating that PDGF-C may have a unique function.

引用

页码：302 / 309

页数：8

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