Application of Polyhydroxyalkanoates in Medicine and the Biological Activity of Natural Poly(3-Hydroxybutyrate)

被引：62

作者：

Bonartsev, A. P. ^{[1
,2
]}

Bonartseva, G. A. ^{[2
]}

Reshetov, I. V. ^{[3
]}

Kirpichnikov, M. P. ^{[1
]}

Shaitan, K. V. ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, Fac Biol, Leninskie Gory 1,Bldg 12, Moscow 119234, Russia

[2] Russian Acad Sci, Biotechnol Res Ctr, AN Bach Inst Biochem, Leninsky Ave 33,Bldg 2, Moscow 119071, Russia

[3] Sechenov First Moscow State Univ, Trubetskaya Str 8,Bldg 2, Moscow 119991, Russia

来源：

ACTA NATURAE | 2019年 / 11卷 / 02期

基金：

俄罗斯基础研究基金会;

关键词：

polyhydroxyalkanoates; poly(3-hydroxybutyrate); biosynthesis; biomimetics; biodegradation; biocompatibility; regenerative medicine; 3-HYDROXYBUTYRATE METHYL-ESTER; ABSORBABLE POLYMER PATCHES; BETA-HYDROXYBUTYRIC ACID; IN-VITRO; BIODEGRADABLE PATCH; DRUG-RELEASE; STEM-CELLS; INFLAMMATORY RESPONSE; MECHANICAL-PROPERTIES; DEGRADATION;

D O I：

10.32607/20758251-2019-11-2-4-16

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biodegradable and biocompatible polymers, polyhydroxyalkanoates (PHAs), are actively used in medicine to produce a wide range of medical devices and dosage formulations. The medical industry mainly utilizes PHAs obtained by chemical synthesis, but interest in the medical application of natural PHAs obtained biotechnologically is also growing. Synthetic PHAs are the biomimetic analogs of bacterial poly(3-hydroxybutyrate) (PHB) and other natural PHAs. This paper addresses the issue of the presence of biological activity in synthetic and natural PHAs (stimulation of cell proliferation and differentiation, tissue regeneration) and their possible association with various biological functions of PHB in bacteria and eukaryotes, including humans.

引用

页码：4 / 16

页数：13

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