The nicotinic acetylcholine receptor partial agonist varenicline and the treatment of drug dependence: A review

被引：46

作者：

Crunelle, Cleo L. ^{[1
,2
,3
]}

Miller, Michelle L. ^{[1
,2
,3
]}

Booij, Jan ^{[3
]}

van den Brink, Wim ^{[1
,2
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Psychiat, NL-1070 AW Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Amsterdam Inst Addict Res, NL-1070 AW Amsterdam, Netherlands

[3] Univ Amsterdam, Acad Med Ctr, Dept Nucl Med, NL-1070 AW Amsterdam, Netherlands

来源：

EUROPEAN NEUROPSYCHOPHARMACOLOGY | 2010年 / 20卷 / 02期

关键词：

Varenicline; Atpha4 beta2 nicotinic acetylcholine receptor; Partial agonist; Addiction; Drug dependence; Relapse prevention; VENTRAL TEGMENTAL AREA; ACCUMBAL DOPAMINE OVERFLOW; VOLUNTARY ETHANOL INTAKE; SMOKING-CESSATION; MOLECULAR-MECHANISMS; MESOLIMBIC DOPAMINE; REINFORCING PROPERTIES; SYNAPTIC-TRANSMISSION; INDUCED HYPERACTIVITY; NUCLEUS-ACCUMBENS;

D O I：

10.1016/j.euroneuro.2009.11.001

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Drug dependence is a chronic brain disease characterized by recurrent episodes of relapse, even when the person is motivated to quit. Relapse is a major problem and new pharmacotherapies are needed to prevent relapse episodes. The nicotinic acetylcholine receptor (nAChR) plays an important rote in nicotine dependence, alcohol consumption and cue-induced cocaine craving. Stimulation of the nAChR has been found to alter and modulate cell firing in brain areas important for the maintenance of drug dependence. Varenicline, an alpha 4 beta 2 nAChR partial agonist and an alpha 7 nAChR full agonist registered for the treatment of nicotine dependence, significantly reduces nicotine craving and prevents relapse. In addition, varenicline reduces alcohol consumption in rats. Based on a review of the available literature, we hypothesize a potential rote for varenicline in the prevention of relapse in patients recovering from drug dependence other than nicotine dependence. (C) 2009 Elsevier B.V. and ECNP. All rights reserved.

引用

页码：69 / 79

页数：11

共 163 条

[1]

[Anonymous], 2014, COCHRANE DB SYST REV, DOI DOI 10.1002/14651858.CD000031.PUB3

[2]

[Anonymous], COCHRANE DATABASE SY

[3]

[Anonymous], COCHRANE DATABASE SY

[4] The role of endocannabinoid transmission in cocaine addiction [J].

Arnold, JC .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2005, 81 (02) :396-406

[5]

Arnsten AFT, 2006, J CLIN PSYCHIAT, V67, P7

[6] Varenicline versus transdermal nicotine patch for smoking cessation: results from a randomised open-label trial [J].

Aubin, H-J ;

Bobak, A. ;

Britton, J. R. ;

Oncken, C. ;

Billing, C. B., Jr. ;

Gong, J. ;

Williams, K. E. ;

Reeves, K. R. .

THORAX, 2008, 63 (08) :717-724

[7] The neurobiology of tobacco dependence: A preclinical perspective on the role of the dopamine projections to the nucleus [J].

Balfour, DJK .

NICOTINE & TOBACCO RESEARCH, 2004, 6 (06) :899-912

[8] Activity of striatal neurons reflects dynamic encoding and recoding of procedural memories [J].

Barnes, TD ;

Kubota, Y ;

Hu, D ;

Jin, DZZ ;

Graybiel, AM .

NATURE, 2005, 437 (7062) :1158-1161

[9] Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions [J].

Bechara, A ;

Tranel, D ;

Damasio, H .

BRAIN, 2000, 123 :2189-2202

[10] Cocaine seeking habits depend upon doparnine-dependent serial connectivity linking the ventral with the dorsal striatum [J].

Belin, David ;

Everitt, Barry J. .

NEURON, 2008, 57 (03) :432-441

← 1 2 3 4 5 6 7 8 9 10 →