Identification of an ortholog of the eukaryotic RNA polymerase III subunit RPC34 in Crenarchaeota and Thaumarchaeota suggests specialization of RNA polymerases for coding and non-coding RNAs in Archaea

被引：28

作者：

Blombach, Fabian ^{[1
]}

Makarova, Kira S. ^{[2
]}

Marrero, Jeannette ^{[3
]}

Siebers, Bettina ^{[3
]}

Koonin, Eugene V. ^{[2
]}

van der Oost, John ^{[1
]}

机构：

[1] Wageningen Univ, Microbiol Lab, Wageningen, Netherlands

[2] Natl Lib Med, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA

[3] Univ Duisburg Essen, Fac Chem, Biofilm Ctr, Duisburg, Germany

来源：

BIOLOGY DIRECT | 2009年 / 4卷

关键词：

TRANSCRIPTION INITIATION; STRUCTURE PREDICTION; EVOLUTION; SEQUENCES; COMPLEXES; PROTEINS; DATABASE; SEARCH; ORIGIN; SERVER;

D O I：

10.1186/1745-6150-4-39

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

One of the hallmarks of eukaryotic information processing is the co-existence of 3 distinct, multi-subunit RNA polymerase complexes that are dedicated to the transcription of specific classes of coding or non-coding RNAs. Archaea encode only one RNA polymerase that resembles the eukaryotic RNA polymerase II with respect to the subunit composition. Here we identify archaeal orthologs of the eukaryotic RNA polymerase III subunit RPC34. Genome context analysis supports a function of this archaeal protein in the transcription of non-coding RNAs. These findings suggest that functional separation of RNA polymerases for protein-coding genes and non-coding RNAs might predate the origin of the Eukaryotes.

引用

页数：7

共 26 条

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