Pulmonary vaccine delivery

被引：109
作者：
Lu, Dongmei [1 ]
Hickey, Anthony J. [1 ]
机构：
[1] Univ N Carolina, Div Mol Pharmaceut, Sch Pharm, Chapel Hill, NC 27599 USA
来源：
EXPERT REVIEW OF VACCINES | 2007年 / 6卷 / 02期
关键词：
aerosol; delivery; device; formulation; vaccine;
D O I：
10.1586/14760584.6.2.213
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This review will discuss developments in the field of pulmonary vaccine delivery. The possibilities of adopting aerosol-generation technology and specific pharmaceutical formulations for the purpose of pulmonary immunization are described. Aerosol-generation systems might offer advantages with respect to vaccine stability and antigenicity. Adjuvants and their inclusion in vaccine-delivery systems are described. Other formulation components, such as surfactants, particulate systems and dispersion of the aerosols are detailed in this paper. The noninvasive, relatively safe and low-cost nature of pulmonary delivery may provide great benefits to the public health vaccination campaign.
引用
收藏
页码：213 / 226
页数：14
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