Dual Role of the Bile Acid Receptor Takeda G-Protein-Coupled Receptor 5 for Hepatic Lipid Metabolism in Feast and Famine

被引:3
作者
Haeussinger, Dieter [1 ]
Keitel, Verena [1 ]
机构
[1] Heinrich Heine Univ, Clin Gastroenterol & Infect Dis, Clin Hepatol & Infect Dis, D-40225 Dusseldorf, Germany
关键词
TGR5; MICE;
D O I
10.1002/hep.29017
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
引用
收藏
页码:767 / 770
页数:4
相关论文
共 11 条
  • [1] G-Protein-Coupled Bile Acid Receptor Plays a Key Role in Bile Acid Metabolism and Fasting-Induced Hepatic Steatosis in Mice
    Donepudi, Ajay C.
    Boehme, Shannon
    Li, Feng
    Chiang, John Y. L.
    [J]. HEPATOLOGY, 2017, 65 (03) : 813 - 827
  • [2] α5β1-integrins are sensors for tauroursodeoxycholic acid in hepatocytes
    Gohlke, Holger
    Schmitz, Birte
    Sommerfeld, Annika
    Reinehr, Roland
    Haeussinger, Dieter
    [J]. HEPATOLOGY, 2013, 57 (03) : 1117 - 1129
  • [3] A G protein-coupled receptor responsive to bile acids
    Kawamata, Y
    Fujii, R
    Hosoya, M
    Harada, M
    Yoshida, H
    Miwa, M
    Fukusumi, S
    Habata, Y
    Itoh, T
    Shintani, Y
    Hinuma, S
    Fujisawa, Y
    Fujino, M
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (11) : 9435 - 9440
  • [4] TGR5: Pathogenetic Role and/or Therapeutic Target in Fibrosing Cholangitis?
    Keitel, Verena
    Reich, Maria
    Haeussinger, Dieter
    [J]. CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 2015, 48 (2-3) : 218 - 225
  • [5] Perspective: TGR5 (Gpbar-1) in liver physiology and disease
    Keitel, Verena
    Haeussinger, Dieter
    [J]. CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY, 2012, 36 (05) : 412 - 419
  • [6] Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice
    Maruyama, Takaharu
    Tanaka, Kenichi
    Suzuki, Jun
    Miyoshi, Hiroyuki
    Harada, Naomoto
    Nakamura, Takao
    Miyamoto, Yasuhisa
    Kanatani, Akio
    Tamai, Yoshitaka
    [J]. JOURNAL OF ENDOCRINOLOGY, 2006, 191 (01) : 197 - 205
  • [7] The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation
    Pols, Thijs W. H.
    Noriega, Lilia G.
    Nomura, Mitsunori
    Auwerx, Johan
    Schoonjans, Kristina
    [J]. JOURNAL OF HEPATOLOGY, 2011, 54 (06) : 1263 - 1272
  • [8] TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro
    Reich, Maria
    Deutschmann, Kathleen
    Sommerfeld, Annika
    Klindt, Caroline
    Kluge, Stefanie
    Kubitz, Ralf
    Ullmer, Christoph
    Knoefel, Wolfram T.
    Herebian, Diran
    Mayatepek, Ertan
    Haeussinger, Dieter
    Keitel, Verena
    [J]. GUT, 2016, 65 (03) : 487 - 501
  • [9] Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist
    Sayin, Sama I.
    Wahlstrom, Annika
    Felin, Jenny
    Jantti, Sirkku
    Marschall, Hanns-Ulrich
    Bamberg, Krister
    Angelin, Bo
    Hyotylainen, Tuulia
    Oresic, Matej
    Backhed, Fredrik
    [J]. CELL METABOLISM, 2013, 17 (02) : 225 - 235
  • [10] TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis
    Thomas, Charles
    Gioiello, Antimo
    Noriega, Lilia
    Strehle, Axelle
    Oury, Julien
    Rizzo, Giovanni
    Macchiarulo, Antonio
    Yamamoto, Hiroyasu
    Mataki, Chikage
    Pruzanski, Mark
    Pellicciari, Roberto
    Auwerx, Johan
    Schoonjans, Kristina
    [J]. CELL METABOLISM, 2009, 10 (03) : 167 - 177