Semisynthetic approaches to laspartomycin analogues

被引:13
作者
Curran, William V. [1 ]
Leese, Richard A.
Jarolmen, Howard
Borders, Donald B.
Dugourd, Dominique
Chen, Yuchen
Cameron, Dale R.
机构
[1] BioSource Pharm Inc, New York, NY 10977 USA
[2] MIGENIX Inc, Vancouver, BC V6S 212, Canada
来源
JOURNAL OF NATURAL PRODUCTS | 2007年 / 70卷 / 03期
关键词
D O I
10.1021/np068062b
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Laspartomycin C (1), a lipopeptide antibiotic related to amphomycin, consists of a cyclic peptide core and an aspartic acid unit external to the core and linking this to a C-15-2,3-unsaturated fatty acid. This was reported initially to be active against Staphylococcus aureus, and more recent studies have shown that it is active against VRE, VISA, and MRSA isolates. The enzymatic cleavage of the fatty acid tail was accomplished with a deacylase produced by Actinoplanes utahensis and resulted in two peptides, designated Peptide 1 and Peptide 2. Semisynthetic derivatives of both peptides have been made, and the principal requirement for biological activity appears to be the presence of an acylaspartic acid.
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收藏
页码:447 / 450
页数:4
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