Development of a computerized system for cytogenetic analysis and classification

被引:1
作者
Pantaleao, CHZ [1 ]
Azevedo, FM [1 ]
Pereira, ET [1 ]
Ribeiro, MCM [1 ]
Marques, JLB [1 ]
机构
[1] Univ Fed Santa Catarina, Inst Biomed Engn, Dept Engn Eletr, BR-88040900 Florianopolis, SC, Brazil
来源
SECOND JOINT EMBS-BMES CONFERENCE 2002, VOLS 1-3, CONFERENCE PROCEEDINGS: BIOENGINEERING - INTEGRATIVE METHODOLOGIES, NEW TECHNOLOGIES | 2002年
关键词
karyotyping systems; fractal geometry; multicriteria methodology;
D O I
10.1109/IEMBS.2002.1053245
中图分类号
TP18 [人工智能理论];
学科分类号
081104 ; 0812 ; 0835 ; 1405 ;
摘要
Microscopic chromosome analysis, denominated of karyotyping, aims the classification of the chromosomes for assessment of their numeric and structural integrity. In the possibility of this process to be computerized, the cytogeneticists use certain types of image processing softwares, denominated of automatic karyotyping systems. The computerized process presents countless advantages, because it would save the cytogeneticists of the most tireless stage of whole the process. However, these automatic karyotyping systems still present some limitations in the identification of the chromosomes when they are overlapping and/or touching, requiring user intervention to perform this task. The objective of this work is to present the development of a computerized system for cytogenetic analysis and classification trying to overcome such limitations. The system is based on the use of techniques of the fractal geometry theory, through an approach of the Hurst Coefficient method and of the Box-Counting Dimension applied in the stage of extraction of the individual chromosomes characteristics. This may prove to be more precise in the identification and classification of the chromosomes. Due to this work possess multidisciplinary characteristics, the multicriteria methodology was applied for structuring the problem through its several stages.
引用
收藏
页码:2211 / 2212
页数:2
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