The Relationship of Mean Platelet Volume/Platelet Distribution Width and Duodenal Ulcer Perforation

Background. Duodenal ulcer perforation (DUP) is a severe acute abdominal disease. Mean platelet volume (MPV) and platelet distribution width (PDW) are two platelet parameters, participating in many inflammatory processes. This study aims to investigate the relation of MPV/PDW and DUP. Methods. A total of 165 patients were studied retrospectively, including 21 females and 144 males. The study included two groups: 87 normal patients (control group) and 78 duodenal ulcer perforation patients (DUP group). Routine blood parameters were collected for analysis including white blood cell count (WBC), neutrophil ratio (NR), platelet count (PLT), MPV and PDW. Receiver operating curve (ROC) analysis was applied to evaluate the parameters' sensitivity. Results. No significant differences were observed between the control group and DUP group in age and gender. WBC, NR and PDW were significantly increased in the DUP group (p < 0.001, respectively); PLT and MPV were significantly decreased in the DUP group (P < 0.001, respectively) compared to controls. MPV had the high sensitivity. Conclusions. Our results suggested a potential association between MPV/PDW and disease activity in DUP patients, and high sensitivity of MPV.