A rapid and transient peripheral inflammatory response precedes brain inflammation after experimental stroke

被引：110

作者：

Chapman, Katie Z. ^{[1
]}

Dale, Verity Q. ^{[2
]}

Denes, Adam ^{[1
]}

Bennett, Gavin ^{[2
]}

Rothwell, Nancy J. ^{[1
]}

Allan, Stuart M. ^{[1
]}

McColl, Barry W. ^{[1
]}

机构：

[1] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England

[2] UCB Celltech Granta Pk, Cambridge, England

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2009年 / 29卷 / 11期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

chemokine; CXCL-1; interleukin-6; MCAo; peripheral inflammation; stroke; CEREBRAL-ISCHEMIA; ACUTE-PHASE; LEUKOCYTE MOBILIZATION; INTERLEUKIN-6; RECRUITMENT; PERMANENT; IMMUNE; INJURY; SYSTEM; LIVER;

D O I：

10.1038/jcbfm.2009.113

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Increasing evidence suggests that peripheral inflammatory responses to stroke and other brain injuries have an important role in determining neurological outcome. The mediators of this response and the temporal relationships between peripheral and central inflammatory alterations are poorly understood. In this study, we show that experimental stroke in mice induces a peripheral inflammatory response that peaks 4 h after stroke, and precedes the peak in brain inflammation 24 h after stroke. This peripheral response is dominated by the induction of the chemokine CXCL-1 and the proinflammatory cytokine interleukin-6 and could serve as an accessible target for therapy and as a source of biomarkers predictive of prognosis. Journal of Cerebral Blood Flow & Metabolism (2009) 29, 1764-1768; doi:10.1038/jcbfm.2009.113; published online 5 August 2009

引用

页码：1764 / 1768

页数：5

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