Mammalian sphingoid bases: Biophysical, physiological and pathological properties

被引：39

作者：

Carreira, A. C. ^{[1
,2
,3
,4
]}

Santos, T. C. ^{[1
,5
,6
]}

Lone, M. A. ^{[6
]}

Zupancic, E. ^{[1
]}

Lloyd-Evans, E. ^{[4
]}

de Almeida, R. F. M. ^{[2
,3
]}

Hornemann, T. E. ^{[5
,6
]}

Silva, L. C. ^{[1
]}

机构：

[1] Univ Lisbon, Fac Farm, iMed ULisboa Res Inst Med, Av Prof Gama Pinto, P-1649003 Lisbon, Portugal

[2] Univ Lisbon, Fac Ciencias, CQB, Ed C8, P-1749016 Lisbon, Portugal

[3] Univ Lisbon, Fac Ciencias, CQE, Ed C8, P-1749016 Lisbon, Portugal

[4] Cardiff Univ, Sch Biosci, Sir Martin Evans Bldg, Cardiff, S Glam, Wales

[5] Univ Lisbon, Ctr Quim Fis Mol, Inst Nanosci & Nanotechnol CQFM IN, Inst Super Tecn,IBB, Lisbon, Portugal

[6] Univ Zurich, Zurich Ctr Integrat Human Physiol ZIHP, Univ Zurich Hosp, Inst Clin Chem, Zurich, Switzerland

来源：

PROGRESS IN LIPID RESEARCH | 2019年 / 75卷

基金：

瑞士国家科学基金会;

关键词：

PROTEIN-KINASE-C; LONG-CHAIN BASES; NIEMANN-PICK-DISEASE; CELL-DEATH; SERINE PALMITOYLTRANSFERASE; FUMONISIN B-1; CANCER-CELLS; IN-VITRO; MASS-SPECTROMETRY; INDUCE APOPTOSIS;

D O I：

10.1016/j.plipres.2019.100988

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sphingoid bases encompass a group of long chain amino alcohols which form the essential structure of sphingolipids. Over the last years, these amphiphilic molecules were moving more and more into the focus of biomedical research due to their role as bioactive molecules. In fact, free sphingoid bases interact with specific receptors and target molecules, and have been associated with numerous biological and physiological processes. In addition, they can modulate the biophysical properties of biological membranes. Several human diseases are related to pathological changes in the structure and metabolism of sphingoid bases. Yet, the mechanisms underlying their biological and pathophysiological actions remain elusive. Within this review, we aimed to summarize the current knowledge on the biochemical and biophysical properties of the most common sphingoid bases and to discuss their importance in health and disease.

引用

页数：17

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