Innovative perspectives of immunotherapy in head and neck cancer. From relevant scientific rationale to effective clinical practice

被引：8

作者：

Lalami, Y. ^{[1
]}

Awada, A. ^{[1
]}

机构：

[1] Univ Libre Bruxelles, Inst Jules Bordet, Med Oncol Clin, Blvd Waterloo, B-1211000 Brussels, Belgium

来源：

CANCER TREATMENT REVIEWS | 2016年 / 43卷

关键词：

Immune system; Head and neck cancer; Tumor immune infiltration; Immunotherapy; HPV; SQUAMOUS-CELL CARCINOMA; REGULATORY T-CELLS; TUMOR-INFILTRATING LYMPHOCYTES; ANTIGEN-PROCESSING MACHINERY; HPV-ASSOCIATED HEAD; LONG-TERM SURVIVAL; HUMAN-PAPILLOMAVIRUS; PHASE-III; OROPHARYNGEAL CANCER; ANTITUMOR IMMUNITY;

D O I：

10.1016/j.ctrv.2016.01.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

It is now well established that head and neck cancer carcinogenesis is characterized by genetic instability and several immune defects, leading to unique host-tumor interactions. In such condition, recent improved comprehension and relevant findings could lead to identification of innovative molecular therapeutic targets, achieving considerable clinical and translational research. This review aims to summarize and to highlight most recent and relevant scientific rationale in this era of immunotherapy revival, and to correlate it to the near future clinical practice for the management of this challenging disease. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：113 / 123

页数：11

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