Innovative perspectives of immunotherapy in head and neck cancer. From relevant scientific rationale to effective clinical practice

被引：8
作者：
Lalami, Y. [1 ]
Awada, A. [1 ]
机构：
[1] Univ Libre Bruxelles, Inst Jules Bordet, Med Oncol Clin, Blvd Waterloo, B-1211000 Brussels, Belgium
来源：
CANCER TREATMENT REVIEWS | 2016年 / 43卷
关键词：
Immune system; Head and neck cancer; Tumor immune infiltration; Immunotherapy; HPV; SQUAMOUS-CELL CARCINOMA; REGULATORY T-CELLS; TUMOR-INFILTRATING LYMPHOCYTES; ANTIGEN-PROCESSING MACHINERY; HPV-ASSOCIATED HEAD; LONG-TERM SURVIVAL; HUMAN-PAPILLOMAVIRUS; PHASE-III; OROPHARYNGEAL CANCER; ANTITUMOR IMMUNITY;
D O I：
10.1016/j.ctrv.2016.01.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
It is now well established that head and neck cancer carcinogenesis is characterized by genetic instability and several immune defects, leading to unique host-tumor interactions. In such condition, recent improved comprehension and relevant findings could lead to identification of innovative molecular therapeutic targets, achieving considerable clinical and translational research. This review aims to summarize and to highlight most recent and relevant scientific rationale in this era of immunotherapy revival, and to correlate it to the near future clinical practice for the management of this challenging disease. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：113 / 123
页数：11
相关论文
共 193 条
  • [11] Prognostic value of tumor-infiltrating CD4+ T-cell subpopulations in head and neck cancers
    Badoual, C
    Hans, S
    Rodriguez, J
    Peyrard, S
    Klein, C
    Agueznay, NE
    Mosseri, V
    Laccourreye, O
    Bruneval, P
    Fridman, WH
    Brasnu, DF
    Tartour, E
    [J]. CLINICAL CANCER RESEARCH, 2006, 12 (02) : 465 - 472
  • [12] PD-1-Expressing Tumor-Infiltrating T Cells Are a Favorable Prognostic Biomarker in HPV-Associated Head and Neck Cancer
    Badoual, Cecile
    Hans, Stephane
    Merillon, Nathalie
    Van Ryswick, Cordelia
    Ravel, Patrice
    Benhamouda, Nadine
    Levionnois, Emeline
    Nizard, Mevyn
    Si-Mohamed, Ali
    Besnier, Nicolas
    Gey, Alain
    Rotem-Yehudar, Rinat
    Pere, Helene
    Tran, Thi
    Guerin, Coralie L.
    Chauvat, Anne
    Dransart, Estelle
    Alanio, Cecile
    Albert, Sebastien
    Barry, Beatrix
    Sandoval, Federico
    Quintin-Colonna, Francoise
    Bruneval, Patrick
    Fridman, Wolf H.
    Lemoine, Francois M.
    Oudard, Stephane
    Johannes, Ludger
    Olive, Daniel
    Brasnu, Daniel
    Tartour, Eric
    [J]. CANCER RESEARCH, 2013, 73 (01) : 128 - 138
  • [13] CHARACTERIZATION OF THE LYMPHOCYTE-ACTIVATION GENE 3-ENCODED PROTEIN - A NEW LIGAND FOR HUMAN-LEUKOCYTE ANTIGEN CLASS-II ANTIGENS
    BAIXERAS, E
    HUARD, B
    MIOSSEC, C
    JITSUKAWA, S
    MARTIN, M
    HERCEND, T
    AUFFRAY, C
    TRIEBEL, F
    PIATIERTONNEAU, D
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (02) : 327 - 337
  • [14] Tumour-infiltrating lymphocytes predict response to definitive chemoradiotherapy in head and neck cancer
    Balermpas, P.
    Michel, Y.
    Wagenblast, J.
    Seitz, O.
    Weiss, C.
    Roedel, F.
    Roedel, C.
    Fokas, E.
    [J]. BRITISH JOURNAL OF CANCER, 2014, 110 (02) : 501 - 509
  • [15] Combination immunotherapy of squamous cell carcinoma of the head and neck - A phase 2 trial
    Barrera, JL
    Verastegui, E
    Meneses, A
    Zinser, J
    de la Garza, J
    Hadden, JW
    [J]. ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 2000, 126 (03) : 345 - 351
  • [16] Oncolytic viruses as therapeutic cancer vaccines
    Bartlett, David L.
    Liu, Zuqiang
    Sathaiah, Magesh
    Ravindranathan, Roshni
    Guo, Zongbi
    He, Yukai
    Guo, Zong Sheng
    [J]. MOLECULAR CANCER, 2013, 12
  • [17] Preferential apoptosis of CD56dim natural killer cell subset in patients with cancer
    Bauernhofer, T
    Kuss, I
    Henderson, B
    Baum, AS
    Whiteside, TL
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2003, 33 (01) : 119 - 124
  • [18] Predicting Recurrence After Radiotherapy in Head and Neck Cancer
    Begg, Adrian C.
    [J]. SEMINARS IN RADIATION ONCOLOGY, 2012, 22 (02) : 108 - 118
  • [19] Harnessing the immune system to treat cancer
    Bhardwaj, Nina
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (05) : 1130 - 1136
  • [20] Safety and Activity of Anti-PD-L1 Antibody in Patients with Advanced Cancer
    Brahmer, Julie R.
    Tykodi, Scott S.
    Chow, Laura Q. M.
    Hwu, Wen-Jen
    Topalian, Suzanne L.
    Hwu, Patrick
    Drake, Charles G.
    Camacho, Luis H.
    Kauh, John
    Odunsi, Kunle
    Pitot, Henry C.
    Hamid, Omid
    Bhatia, Shailender
    Martins, Renato
    Eaton, Keith
    Chen, Shuming
    Salay, Theresa M.
    Alaparthy, Suresh
    Grosso, Joseph F.
    Korman, Alan J.
    Parker, Susan M.
    Agrawal, Shruti
    Goldberg, Stacie M.
    Pardoll, Drew M.
    Gupta, Ashok
    Wigginton, Jon M.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (26) : 2455 - 2465
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