Neutrophil-to-lymphocyte ratio: An effective predictor of corticosteroid response in IgA nephropathy

被引:12
作者
Yang, Hu [1 ]
Zhang, Weiwei [1 ]
Li, Ying [1 ]
Li, Rong [1 ]
机构
[1] Tianjin Med Univ, Dept Nephrol, Hosp 2, Tianjin 300211, Peoples R China
关键词
IgA nephropathy; Corticosteroid; Neutrophil-to-lymphocyte ratio; Glomerulonephritis; OUTCOMES; THERAPY;
D O I
10.1016/j.intimp.2019.105678
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background: The neutrophil-to-lymphocyte ratio (NLR) has been shown to have a strong predictive ability for the prognosis of various diseases. However, the role of the NLR in IgA nephropathy is currently unknown. In this study, we attempted to evaluate how useful the NLR is for predicting corticosteroid response in IgA nephropathy. Methods: For retrospective cohort with IgA nephropathy, the patients who received corticosteroid therapy were recruited. To identify independent factors for corticosteroid response, the NLR and other parameters were analyzed using the multivariate regression model. The predictive usefulness was determined by the area under the receiver operating characteristics curve (AUROC). Survival analysis was conducted to compare the corticosteroid response between different groups according to the cut-off of NLR. Results: Multivariate analyses showed that NLR, serum creatinine, uric acid, and estimated glomerular filtration rate (eGFR) were independent factors for corticosteroid response. The AUROC of NLR (0.748) was higher than those of other factors. Patients with NLRs < 2.43 had a higher remission rate than those with NLR >= 2.43 (P < 0.001). Conclusion: NLR is an effective predictor of corticosteroid response in IgA nephropathy.
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页数:5
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共 27 条
  • [1] Neutrophil-Lymphocyte Ratio as a Predictor of Adverse Outcomes of Acute Pancreatitis
    Azab, Basem
    Jaglall, Neil
    Atallah, Jean Paul
    Lamet, Ari
    Raja-Surya, Venkat
    Farah, Bachir
    Lesser, Martin
    Widmann, Warren D.
    [J]. PANCREATOLOGY, 2011, 11 (04) : 445 - 452
  • [2] A novel predictive model based on preoperative blood neutrophil-to-lymphocyte ratio for survival prognosis in patients with gastric neuroendocrine neoplasms
    Cao, Long-Long
    Lu, Jun
    Lin, Jian-Xian
    Zheng, Chao-Hui
    Li, Ping
    Xie, Jian-Wei
    Wang, Jia-Bin
    Chen, Qi-Yue
    Lin, Mi
    Tu, Ru-Hong
    Huang, Chang-Ming
    [J]. ONCOTARGET, 2016, 7 (27) : 42045 - 42058
  • [3] Neutrophil-to-lymphocyte ratio as an independent predictor for survival in patients with localized clear cell renal cell carcinoma after radiofrequency ablation: a propensity score matching analysis
    Chang, Xiaofeng
    Zhang, Fan
    Liu, Tieshi
    Wang, Wei
    Guo, Hongqian
    [J]. INTERNATIONAL UROLOGY AND NEPHROLOGY, 2017, 49 (06) : 967 - 974
  • [4] ACEI/ARB therapy for IgA nephropathy: a meta analysis of randomised controlled trials
    Cheng, J.
    Zhang, W.
    Zhang, X. H.
    He, Q.
    Tao, X. J.
    Chen, J. H.
    [J]. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2009, 63 (06) : 880 - 888
  • [5] Analysis of the relationship between Oxford classification, IgM deposition and multiple indexes and the adverse prognosis of patients with primary IgA nephropathy and related risk factors
    Hao, Yan
    Zhao, Yuliang
    Huang, Rongshuang
    Fu, Ping
    [J]. EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2019, 17 (02) : 1234 - 1239
  • [6] Jarrick S., 2019, MORTALITY IGA NEPHRO
  • [7] Efficacy and safety of angiotensin-converting enzyme inhibitors/angiotensin receptor blocker therapy for IgA nephropathy: A meta-analysis of randomized controlled trials
    Ji, Yue
    Yang, Kang
    Xiao, Bo
    Lin, Jin
    Zhao, Qingyun
    Bhuva, Maheshkumar Satishkumar
    Yang, Hongtao
    [J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 2019, 120 (03) : 3689 - 3695
  • [8] Association of neutrophil-to-lymphocyte ratio with early renal dysfunction and albuminuria among diabetic patients
    Kawamoto, Ryuichi
    Ninomiya, Daisuke
    Kikuchi, Asuka
    Akase, Taichi
    Kasai, Yoshihisa
    Kusunoki, Tomo
    Ohtsuka, Nobuyuki
    Kumagi, Teru
    [J]. INTERNATIONAL UROLOGY AND NEPHROLOGY, 2019, 51 (03) : 483 - 490
  • [9] The neutrophil-to-lymphocyte ratio makes the Heng risk model improve better the prediction of overall survival in metastatic renal cell cancer patients
    Kim, Sung Han
    Kwon, Whi-An
    Kim, Sohee
    Joung, Jae Young
    Seo, Ho Kyung
    Lee, Kang Hyun
    Chung, Jinsoo
    [J]. JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2018, 48 (09) : 835 - 840
  • [10] Age and sex differences in the relationship between neutrophil-to-lymphocyte ratio and chronic kidney disease among an adult population in Taiwan
    Kuo, Yi-Ting
    Wang, Ya-Yu
    Lin, Shih-Yi
    Chang, Wen-Dau
    [J]. CLINICA CHIMICA ACTA, 2018, 486 : 98 - 103