Modeling collagen remodeling

被引:63
作者
Baaijens, Frank [1 ]
Bouten, Carlijn [1 ]
Driessen, Niels [1 ]
机构
[1] Tech Univ Eindhoven, Dept Biomed Engn, NL-5600 MB Eindhoven, Netherlands
关键词
Collagen; Remodeling; Cardiovascular; Tissue engineering; Computational; STRUCTURAL CONSTITUTIVE MODEL; BIAXIAL MECHANICAL-PROPERTIES; HEART-VALVE LEAFLETS; TISSUE-EQUIVALENT MECHANICS; ANISOTROPIC BIPHASIC THEORY; NATIVE BOVINE PERICARDIUM; CARDIAC FIBER ORIENTATION; VASCULAR SMOOTH-MUSCLE; STRAIN-ENERGY DENSITY; HUMAN BRAIN ARTERIES;
D O I
10.1016/j.jbiomech.2009.09.022
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Collagen is the main load bearing protein in many soft tissues, and in cardiovascular tissues in particular. In many tissues collagen has a specific architecture that is crucial for the biomechanical function of the tissue. Typical examples are the hammock-shaped collagen architecture in heart valves and a helical pattern in arteries. One of the objectives in cardiovascular tissue engineering is the reconstitution of this architecture. It is hypothesized that the architecture is mediated by mechanical stimulation. Computational models were developed to predict the mechanoregulation of the collagen architecture. This review recapitulates the key modeling assumptions and results achieved to date. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:166 / 175
页数:10
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