The role of 14-3-3 proteins in cell signalling pathways and virus infection

被引：44

作者：

Liu, Jiaqi ^{[1
,2
]}

Cao, Shengliang ^{[1
,2
]}

Ding, Guofei ^{[1
,2
]}

Wang, Bin ^{[1
,2
]}

Li, Yingchao ^{[1
,2
]}

Zhao, Yuzhong ^{[1
,2
]}

Shao, Qingyuan ^{[1
,2
]}

Feng, Jian ^{[1
,2
]}

Liu, Sidang ^{[1
,2
]}

Qin, Liting ^{[3
,4
]}

Xiao, Yihong ^{[1
,2
]}

机构：

[1] Shandong Agr Univ, Coll Anim Sci & Vet Med, Dept Fundamental Vet Med, 61 Daizong St, Tai An 271018, Shandong, Peoples R China

[2] Shandong Agr Univ, Shandong Prov Key Lab Anim Biotechnol & Dis Contr, Tai An, Shandong, Peoples R China

[3] Shandong New Hope Liuhe Grp Co Ltd, Qingdao, Peoples R China

[4] Qingdao Jiazhi Biotechnol Co Ltd, Qingdao, Peoples R China

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2021年 / 25卷 / 09期

基金：

中国国家自然科学基金;

关键词：

14‐ 3‐ 3; proteins; biological function; innate immunity; viral infection; DNA-DAMAGE CHECKPOINT; NF-KAPPA-B; RIG-I; KINASE; BINDING; PHOSPHORYLATION; TRANSCRIPTION; 14-3-3-PROTEINS; PHOSPHATASE; INHIBITION;

D O I：

10.1111/jcmm.16490

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

14-3-3 proteins are highly conserved in species ranging from yeast to mammals and regulate numerous signalling pathways via direct interactions with proteins carrying phosphorylated 14-3-3-binding motifs. Recent studies have shown that 14-3-3 proteins can also play a role in viral infections. This review summarizes the biological functions of 14-3-3 proteins in protein trafficking, cell-cycle control, apoptosis, autophagy and other cell signal transduction pathways, as well as the associated mechanisms. Recent findings regarding the role of 14-3-3 proteins in viral infection and innate immunity are also reviewed.

引用

页码：4173 / 4182

页数：10

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