Iodide-Selective Synthetic Ion Channels Based on Shape-Persistent Organic Cages

被引：97

作者：

Benke, Bahiru Punja ^{[1
]}

Aich, Pulakesh ^{[1
]}

Kim, Younghoon ^{[2
]}

Kim, Kyung Lock ^{[1
]}

Rohman, Md Rumum ^{[1
]}

Hong, Soonsang ^{[1
,2
]}

Hwang, In-Chul ^{[1
]}

Lee, Eun Hui ^{[3
]}

Roh, Joon Ho ^{[1
]}

Kim, Kimoon ^{[1
,2
]}

机构：

[1] Inst for Basic Sci Korea, Ctr Selfassembly & Complex CSC, Pohang 37673, South Korea

[2] Pohang Univ Sci & Technol, Dept Chem, Pohang 37673, South Korea

[3] Catholic Univ Korea, Coll Med, Dept Physiol, Seoul 06591, South Korea

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2017年 / 139卷 / 22期

关键词：

ANION-PI SLIDES; MEMBRANE TRANSPORTERS; CHLORIDE TRANSPORT; PEPTIDE; PORES; MECHANISM;

D O I：

10.1021/jacs.7b02708

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report here a synthetic ion channel developed from a shape-persistent porphyrin-based covalent organic cage. The cage was synthesized by employing a synthetically economical dynamic covalent chemistry (DCC) approach. The organic cage selectively transports biologically relevant iodide ions over other inorganic anions by a dehydration-driven, channel mechanism as evidenced by vesicle-based fluorescence assays and planar lipid bilayer-based single channel recordings. Furthermore, the organic cage appears to facilitate iodide transport across the membrane of a hying cell, suggesting that the cage could be useful as a biological tool that may replace defective iodide channels in living systems:

引用

页码：7432 / 7435

页数：4