New trends in hair analysis and scientific demands on validation and technical notes

被引：92

作者：

Musshoff, Frank ^{[1
]}

Madea, Burkhard ^{[1
]}

机构：

[1] Univ Bonn, Inst Forens Med, D-53111 Bonn, Germany

来源：

FORENSIC SCIENCE INTERNATIONAL | 2007年 / 165卷 / 2-3期

基金：

英国工程与自然科学研究理事会;

关键词：

hair testing; validation; drugs; THC-COOH; SPME;

D O I：

10.1016/j.forsciint.2006.05.024

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

This review focuses on basic aspects of method development and validation of hair testing procedures. Quality assurance is a major issue in drug testing in hair resulting in new recommendations, validation procedures and inter-laboratory comparisons. Furthermore recent trends in research concerning hair analysis are discussed, namely mechanisms of drug incorporation and retention, novel analytical procedures (especially ones using liquid chromatography-mass spectrometry (LC-MS) and alternative sample preparation techniques like solid-phase microextraction (SPME)), the determination of THC-COOH in hair samples, hair testing in drug-facilitated crimes, enantioselective hair testing procedures and the importance of hair analysis in clinical trials. Hair testing in analytical toxicology is still an area in need of further research. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：204 / 215

页数：12

共 159 条

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