VIEWPOINT Induced pluripotent stem cells and reprogramming: seeing the science through the hype

被引：72
作者：
Belmonte, Juan Carlos Izpisua [1 ,2 ]
Ellis, James [3 ,4 ]
Hochedlinger, Konrad [5 ,6 ,7 ]
Yamanaka, Shinya [8 ]
机构：
[1] Ctr Regenerat Med Barcelona, Barcelona 08003, Spain
[2] Salk Inst Biol Studies, La Jolla, CA 93027 USA
[3] Hosp Sick Children, Toronto, ON M5G 1L7, Canada
[4] MaRS Ctr, Ontario Human iPS Cell Facil, Toronto, ON M5G 1L7, Canada
[5] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA
[6] Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
[7] Harvard Stem Cell Inst, Ctr Regenerat Med, Boston, MA 02114 USA
[8] Inst Frontier Med Sci, Dept Stem Cell Biol, Inst Integrated Cell Mat Sci iCeMS, Ctr iPS Cell Res & Applicat CiRA,Shogoin Sakyo Ku, Kyoto 6068507, Japan
来源：
NATURE REVIEWS GENETICS | 2009年 / 10卷 / 12期
关键词：
GENERATION;
D O I：
10.1038/nrg2700
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
No-one can have failed to notice the splash that induced pluripotent stem (iPS) cells have made in the few years since somatic cells were first reprogrammed to pluripotency. But what is their real promise, where should research efforts be focused, and are we at a stage where we can replace embryonic stem cells? Four pioneering iPS cell researchers offer their personal insights into these and other questions of current debate. As well expressing hope for the improved understanding and treatment of human disease, they urge caution over safety and propose the establishment of iPS cell banks.
引用
收藏
页码：878 / U80
页数：6
相关论文
共 21 条
  • [1] Senescence impairs successful reprogramming to pluripotent stem cells
    Banito, Ana
    Rashid, Sheikh T.
    Acosta, Juan Carlos
    Li, SiDe
    Pereira, Carlos F.
    Geti, Imbisaat
    Pinho, Sandra
    Silva, Jose C.
    Azuara, Veronique
    Walsh, Martin
    Vallier, Ludovic
    Gil, Jesus
    [J]. GENES & DEVELOPMENT, 2009, 23 (18) : 2134 - 2139
  • [2] Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons
    Dimos, John T.
    Rodolfa, Kit T.
    Niakan, Kathy K.
    Weisenthal, Laurin M.
    Mitsumoto, Hiroshi
    Chung, Wendy
    Croft, Gist F.
    Saphier, Genevieve
    Leibel, Rudy
    Goland, Robin
    Wichterle, Hynek
    Henderson, Christopher E.
    Eggan, Kevin
    [J]. SCIENCE, 2008, 321 (5893) : 1218 - 1221
  • [3] Induced pluripotent stem cells from a spinal muscular atrophy patient
    Ebert, Allison D.
    Yu, Junying
    Rose, Ferrill F., Jr.
    Mattis, Virginia B.
    Lorson, Christian L.
    Thomson, James A.
    Svendsen, Clive N.
    [J]. NATURE, 2009, 457 (7227) : 277 - U1
  • [4] Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin
    Hanna, Jacob
    Wernig, Marius
    Markoulaki, Styliani
    Sun, Chiao-Wang
    Meissner, Alexander
    Cassady, John P.
    Beard, Caroline
    Brambrink, Tobias
    Wu, Li-Chen
    Townes, Tim M.
    Jaenisch, Rudolf
    [J]. SCIENCE, 2007, 318 (5858) : 1920 - 1923
  • [5] Suppression of induced pluripotent stem cell generation by the p53-p21 pathway
    Hong, Hyenjong
    Takahashi, Kazutoshi
    Ichisaka, Tomoko
    Aoi, Takashi
    Kanagawa, Osami
    Nakagawa, Masato
    Okita, Keisuke
    Yamanaka, Shinya
    [J]. NATURE, 2009, 460 (7259) : 1132 - 1135
  • [6] Hotta A, 2009, NAT METHODS, V6, P370, DOI [10.1038/NMETH.1325, 10.1038/nmeth.1325]
  • [7] Linking the p53 tumour suppressor pathway to somatic cell reprogramming
    Kawamura, Teruhisa
    Suzuki, Jotaro
    Wang, Yunyuan V.
    Menendez, Sergio
    Batlle Morera, Laura
    Raya, Angel
    Wahl, Geoffrey M.
    Izpisua Belmonte, Juan Carlos
    [J]. NATURE, 2009, 460 (7259) : 1140 - 1144
  • [8] Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs
    Lee, Gabsang
    Papapetrou, Eirini P.
    Kim, Hyesoo
    Chambers, Stuart M.
    Tomishima, Mark J.
    Fasano, Christopher A.
    Ganat, Yosif M.
    Menon, Jayanthi
    Shimizu, Fumiko
    Viale, Agnes
    Tabar, Viviane
    Sadelain, Michel
    Studer, Lorenz
    [J]. NATURE, 2009, 461 (7262) : 402 - U100
  • [9] The Ink4/Arf locus is a barrier for iPS cell reprogramming
    Li, Han
    Collado, Manuel
    Villasante, Aranzazu
    Strati, Katerina
    Ortega, Sagrario
    Canamero, Marta
    Blasco, Maria A.
    Serrano, Manuel
    [J]. NATURE, 2009, 460 (7259) : 1136 - 1139
  • [10] A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
    Marion, Rosa M.
    Strati, Katerina
    Li, Han
    Murga, Matilde
    Blanco, Raquel
    Ortega, Sagrario
    Fernandez-Capetillo, Oscar
    Serrano, Manuel
    Blasco, Maria A.
    [J]. NATURE, 2009, 460 (7259) : 1149 - 1153
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