Serum Aβ Levels are Associated with Age-related Cataract

To investigate the levels and clinical relevance of serum beta-amyloid (A beta) in age-related cataract (ARC) patients. In the present study, an overall of 402 ARC patients and 450 normal controls were recruited between June 2018 and December 2019. Serum A beta 1-40 and A beta 1-42 concentrations were assessed by Elisa. The ARC patients were further grouped into several subgroups according to gender, age, types of ARC, and degree of lens opacity. The association of A beta levels with ARC was determined using logistic regression models. ARC patients had significantly higher serum A beta 1-40 and A beta 1-42 levels than normal control. A similar finding was observed in subjects aged over 60 years. Serum A beta concentrations were significant correlated with the degrees of lens opacity in C-ARC and N-ARC subjects. Logistic regression analyses revealed that serum A beta 1-40 (ORs = 1.202, 95% CI 1.077 to 1.341) and A beta 1-42 (ORs = 1.686, 95% CI 1.351 to 2.103) levels were potential risk factors for ARC. ARC patients have higher serum A beta 1-40, as well as A beta 1-42 levels, which may reflect an association between A beta and ARC pathogenesis. Serum A beta 1-42 and A beta 1-40 levels are potential risk factors for ARC.