Fornix-Region Deep Brain Stimulation-Induced Memory Flashbacks in Alzheimer's Disease

被引:39
作者
Deeb, Wissam [1 ]
Salvato, Bryan [2 ]
Almeida, Leonardo [1 ]
Foote, Kelly D. [1 ]
Amaral, Robert [3 ]
Germann, Jurgen [3 ]
机构
[1] Univ Florida, Gainesville, FL 32611 USA
[2] Florida State Univ, Tallahassee, FL 32306 USA
[3] Douglas Mental Hlth Univ, Res Inst, Montreal, PQ, Canada
关键词
D O I
10.1056/NEJMc1905240
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In a trial of stimulation of the fornix and subcallosal regions of the hippocampus involving 42 patients with Alzheimer's disease, 20 patients reported vivid memory flashbacks. The robustness and complexity of the memories increased with increasing voltage applied to the stimulating electrodes.
引用
收藏
页码:783 / 785
页数:3
相关论文
共 4 条
[1]   Memory scrutinized through electrical brain stimulation: A review of 80 years of experiential phenomena [J].
Curot, Jonathan ;
Busigny, Thomas ;
Valton, Luc ;
Denuelle, Marie ;
Vignal, Jean-Pierre ;
Maillard, Louis ;
Chauvel, Patrick ;
Pariente, Jeremie ;
Trebuchon, Agnes ;
Bartolomei, Fabrice ;
Barbeau, Emmanuel J. .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2017, 78 :161-177
[2]   Compensatory Shift of Subcallosal Area and Paraterminal Gyrus White Matter Parameters on DTI in Patients with Alzheimer Disease [J].
Kuchtova, Barbora ;
Wurst, Zdenek ;
Mrzilkova, Jana ;
Ibrahim, Ibrahim ;
Tintera, Jaroslav ;
Bartos, Ales ;
Musil, Vladimir ;
Kieslich, Karel ;
Zach, Petr .
CURRENT ALZHEIMER RESEARCH, 2018, 15 (06) :590-599
[3]   A Phase II Study of Fornix Deep Brain Stimulation in Mild Alzheimer's Disease [J].
Lozano, Andres M. ;
Fosdick, Lisa ;
Chakravarty, M. Mallar ;
Leoutsakos, Jeannie-Marie ;
Munro, Cynthia ;
Oh, Esther ;
Drake, Kristen E. ;
Lyman, Christopher H. ;
Rosenberg, Paul B. ;
Anderson, William S. ;
Tang-Wai, David F. ;
Pendergrass, Jo Cara ;
Salloway, Stephen ;
Asaad, Wael F. ;
Ponce, Francisco A. ;
Burke, Anna ;
Sabbagh, Marwan ;
Wolk, David A. ;
Baltuch, Gordon ;
Okun, Michael S. ;
Foote, Kelly D. ;
McAndrews, Mary Pat ;
Giacobbe, Peter ;
Targum, Steven D. ;
Lyketsos, Constantine G. ;
Smith, Gwenn S. .
JOURNAL OF ALZHEIMERS DISEASE, 2016, 54 (02) :777-787
[4]   BRAINS RECORD OF AUDITORY AND VISUAL EXPERIENCE - A FINAL SUMMARY AND DISCUSSION [J].
PENFIELD, W ;
PEROT, P .
BRAIN, 1963, 86 (04) :595-&