Cardiac Toxicity of Thoracic Radiotherapy: Existing Evidence and Future Directions

被引：169

作者：

Banfill, Kathryn ^{[1
,2
]}

Giuliani, Meredith ^{[3
,4
]}

Aznar, Marianne ^{[1
]}

Franks, Kevin ^{[5
,6
]}

McWilliam, Alan ^{[1
,2
]}

Schmitt, Matthias ^{[7
]}

Sun, Fei ^{[5
,6
]}

Vozenin, Marie Catherine ^{[8
,9
]}

Finn, Corinne Faivre ^{[1
]}

机构：

[1] Univ Manchester, Fac Biol Med & Hlth, Div Canc Sci, Manchester M20 4BX, Lancs, England

[2] Christie NHS Fdn Trust, Manchester, Lancs, England

[3] Princess Margaret Canc Ctr, Radiat Med Program, Toronto, ON, Canada

[4] Univ Toronto, Dept Radiat Oncol, Toronto, ON, Canada

[5] St James Univ Hosp, Leeds Teaching Hosp NHS Trust, Leeds Canc Ctr, Leeds, W Yorkshire, England

[6] Univ Leeds, Fac Med & Hlth, Leeds Inst Med Res St Jamess, Radiotherapy Res Grp, Leeds, W Yorkshire, England

[7] Manchester Univ Fdn Trust, North West Heart Ctr, Cardiovasc Div, Wythenshawe Campus, Manchester, Lancs, England

[8] Univ Lausanne Hosp, CHUV, Lab Radiat Oncol DO Radiooncol, Lausanne, Switzerland

[9] Univ Lausanne, Lausanne, Switzerland

来源：

JOURNAL OF THORACIC ONCOLOGY | 2021年 / 16卷 / 02期

基金：

英国医学研究理事会;

关键词：

Lung cancer; Radiotherapy; Cardiac toxicity; Cardio-oncology; Dose-volume; LUNG-CANCER PATIENTS; CORONARY-HEART-DISEASE; RADIATION-THERAPY; CARDIOVASCULAR-DISEASE; IONIZING-RADIATION; RISK; SURVIVAL; IMPACT; ATLAS; CHEMORADIATION;

D O I：

10.1016/j.jtho.2020.11.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The impact of radiotherapy on the heart has become an area of interest in recent years. Many different cardiac dose-volume constraints have been associated with cardiac toxicity and survival; however, no consistent constraint has been found. Many patients undergoing treatment for lung cancer have risk factors for cardiovascular disease or known cardiac comorbidities; however, there is little evidence on the effects of radiotherapy on the heart in these patients. We aim to provide a summary of the existing literature on cardiac toxicity of lung cancer radiotherapy, propose strategies to avoid and manage cardiac toxicity, and suggest avenues for future research. (C) 2020 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.

引用

页码：216 / 227

页数：12

共 74 条

[1] Radiotherapy-Related Lymphopenia Affects Overall Survival in Patients With Lung Cancer [J].

Abravan, Azadeh ;

Faivre-Finn, Corinne ;

Kennedy, Jason ;

McWilliam, Alan ;

van Herk, Marcel .

JOURNAL OF THORACIC ONCOLOGY, 2020, 15 (10) :1624-1635

[2] Cardiac Radiation Dose, Cardiac Disease, and Mortality in Patients With Lung Cancer [J].

Atkins, Katelyn M. ;

Rawal, Bhupendra ;

Chaunzwa, Tafadzwa L. ;

Lamba, Nayan ;

Bitterman, Danielle S. ;

Williams, Christopher L. ;

Kozono, David E. ;

Baldini, Elizabeth H. ;

Chen, Aileen B. ;

Nguyen, Paul L. ;

D'Amico, Anthony V. ;

Nohria, Anju ;

Hoffmann, Udo ;

Aerts, Hugo J. W. L. ;

Mak, Raymond H. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2019, 73 (23) :2976-2987

[3] Targeted lung cancer screening selects individuals at high risk of cardiovascular disease [J].

Balata, H. ;

Knight, S. Blandin ;

Barber, P. ;

Colligan, D. ;

Crosbie, E. J. ;

Duerden, R. ;

Elton, P. ;

Evison, M. ;

Greaves, M. ;

Howells, J. ;

Irion, K. ;

Karunaratne, D. ;

Kirwan, M. ;

Macnab, A. ;

Mellor, S. ;

Miller, C. ;

Newton, T. ;

Novasio, J. ;

Sawyer, R. ;

Sharman, A. ;

Slevin, K. ;

Smith, E. ;

Taylor, B. ;

Taylor, S. ;

Tonge, J. ;

Walsham, A. ;

Waplington, S. ;

Whittaker, J. ;

Booton, R. ;

Crosbie, P. A. J. .

LUNG CANCER, 2018, 124 :148-153

[4] Effects of ionizing radiation on the heart [J].

Boerma, Marjan ;

Sridharan, Vijayalakshmi ;

Mao, Xiao-Wen ;

Nelson, Gregory A. ;

Cheema, Amrita K. ;

Koturbash, Igor ;

Singh, Sharda P. ;

Tackett, Alan J. ;

Hauer-Jensen, Martin .

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH, 2016, 770 :319-327

[5] Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study [J].

Bradley, Jeffrey D. ;

Paulus, Rebecca ;

Komaki, Ritsuko ;

Masters, Gregory ;

Blumenschein, George ;

Schild, Steven ;

Bogart, Jeffrey ;

Hu, Chen ;

Forster, Kenneth ;

Magliocco, Anthony ;

Kavadi, Vivek ;

Garces, Yolanda I. ;

Narayan, Samir ;

Iyengar, Puneeth ;

Robinson, Cliff ;

Wynn, Raymond B. ;

Koprowski, Christopher ;

Meng, Joanne ;

Beitler, Jonathan ;

Gaur, Rakesh ;

Curran, Walter, Jr. ;

Choy, Hak .

LANCET ONCOLOGY, 2015, 16 (02) :187-199

[6] Vascular Complications of Cancer Chemotherapy [J].

Cameron, Alan C. ;

Touyz, Rhian M. ;

Lang, Ninian N. .

CANADIAN JOURNAL OF CARDIOLOGY, 2016, 32 (07) :852-862

[7] Impact of Intensity-Modulated Radiation Therapy Technique for Locally Advanced Non-Small-Cell Lung Cancer: A Secondary Analysis of the NRG Oncology RTOG 0617 Randomized Clinical Trial [J].

Chun, Stephen G. ;

Hu, Chen ;

Choy, Hak ;

Komaki, Ritsuko U. ;

Timmerman, Robert D. ;

Schild, Steven E. ;

Bogart, Jeffrey A. ;

Dobelbower, Michael C. ;

Bosch, Walter ;

Galvin, James M. ;

Kavadi, Vivek S. ;

Narayan, Samir ;

Iyengar, Puneeth ;

Robinson, Clifford G. ;

Wynn, Raymond B. ;

Raben, Adam ;

Augspurger, Mark E. ;

MacRae, RobertM. ;

Paulus, Rebecca ;

Bradley, Jeffrey D. .

JOURNAL OF CLINICAL ONCOLOGY, 2017, 35 (01) :56-+

[8] Cardiac dose is associated with immunosuppression and poor survival in locally advanced non-small cell lung cancer [J].

Contreras, Jessika A. ;

Lin, Alexander J. ;

Weiner, Ashley ;

Speirs, Christina ;

Samson, Pamela ;

Mullen, Daniel ;

Campian, Jian ;

Bradley, Jeffrey ;

Roach, Michael ;

Robinson, Clifford .

RADIOTHERAPY AND ONCOLOGY, 2018, 128 (03) :498-504

[9] Second round results from the Manchester 'Lung Health Check' community-based targeted lung cancer screening pilot [J].

Crosbie, Phil A. ;

Balata, Haval ;

Evison, Matthew ;

Atack, Melanie ;

Bayliss-Brideaux, Val ;

Colligan, Denis ;

Duerden, Rebecca ;

Eaglesfield, Josephine ;

Edwards, Timothy ;

Elton, Peter ;

Foster, Julie ;

Greaves, Melanie ;

Hayler, Graham ;

Higgins, Coral ;

Howells, John ;

Irion, Klaus ;

Karunaratne, Devinda ;

Kelly, Jodie ;

King, Zoe ;

Lyons, Judith ;

Manson, Sarah ;

Mellor, Stuart ;

Miller, Donna ;

Myerscough, Amanda ;

Newton, Tom ;

O'Leary, Michelle ;

Pearson, Rachel ;

Pickford, Julie ;

Sawyer, Richard ;

Screaton, Nick J. ;

Sharman, Anna ;

Simmons, Maggi ;

Smith, Elaine ;

Taylor, Ben ;

Taylor, Sarah ;

Walsham, Anna ;

Watts, Angela ;

Whittaker, James ;

Yarnell, Laura ;

Threlfall, Anthony ;

Barber, Phil V. ;

Tonge, Janet ;

Booton, Richard .

THORAX, 2019, 74 (07) :700-704

[10] Noninvasive Cardiac Radiation for Ablation of Ventricular Tachycardia [J].

Cuculich, Phillip S. ;

Schill, Matthew R. ;

Kashani, Rojano ;

Mutic, Sasa ;

Lang, Adam ;

Cooper, Daniel ;

Faddis, Mitchell ;

Gleva, Marye ;

Noheria, Amit ;

Smith, Timothy W. ;

Hallahan, Dennis ;

Rudy, Yoram ;

Robinson, Clifford G. .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (24) :2325-2336

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