Intravenous CCK-8, but not GLP-1, suppresses ghrelin and stimulates PYY release in healthy men

被引：54
作者：
Brennan, Ixchel M.
Otto, Baerbel
Feltrin, Kate L.
Meyer, James H.
Horowitz, Michael
Feinle-Bisset, Christine [1 ]
机构：
[1] Univ Adelaide, Royal Adelaide Hosp, Discipline Med, Adelaide, SA 5000, Australia
[2] Univ Munich, Med Klin, Klinikum Innenstadt, Munich, Germany
来源：
PEPTIDES | 2007年 / 28卷 / 03期
基金：
英国医学研究理事会;
关键词：
cholecystokinin; glucagon-like peptide-1; peptide YY; ghrelin;
D O I：
10.1016/j.peptides.2006.10.014
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have investigated the effects of exogenous CCK-8 and GLP-1, alone and in combination, on ghrelin and PYY secretion. Nine healthy males were studied on four occasions. Plasma ghrelin and PYY concentrations were measured during 150 min intravenous infusions of: (i) isotonic saline, (ii) CCK-8 at 1.8 pmol/kg/min, (iii) GLP-1 at 0.9 pmol/kg/min or (iv) CCK-8 and GLP-1 combined. CCK-8 markedly suppressed ghrelin and stimulated PYY when compared with control between t = 0-120 min (P < 0.001 for both). GLP-1 had no effect on ghrelin, but decreased PYY slightly at 120 min (P < 0.05). During infusion of CCK-8 + GLP-1, there was comparable suppression of ghrelin (P < 0.001), but the stimulation of PYY was less (P < 0.001), than that induced by CCK-8, between t = 20-120 min. In conclusion, in healthy subjects, in the doses evaluated, exogenous CCK-8 suppresses ghrelin and stimulates PYY, and exogenous GLP-1 has no effect on ghrelin and attenuates the effect of CCK-8 on PYY. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码：607 / 611
页数：5
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