The interplay of vitamin D and body mass index in acne patients vs. controls

Background Acne vulgaris is a disease of pilosebaceous units and manifests with polymorphic lesions. Vitamin D acts at various stages in its pathogenesis. Recently, vitamin D and metabolic syndrome have shown to be associated with acne vulgaris and its severity. Aims To see the effects of serum 25(OH)D3 levels and body mass index on acne vulgaris and their correlation with the severity of acne. Patients/Methods Fifty patients of acne vulgaris and thirty age- and sex-matched healthy volunteers were recruited. Global Acne Grading System was used to grade the acne severity. Body mass index of all patients and control group was calculated, and serum levels of 25(OH)D3 were measured using chemiluminescence immunoassay. Results Vitamin D deficiency was detected in 28% of patients with acne but only in 6.7% of the healthy controls (p value 0.022). However, there was no significant difference in mean serum 25(OH)D levels in acne patients and controls. Vitamin D deficiency was seen in 60% of the very severe and 33% of the severe acne cases. Eighty percent of patients with very severe acne and 73.33% of severe acne patients had high body mass index. The relationship between severity of acne and body mass index was statistically significant. Conclusion Vitamin D deficiency was more prevalent in acne, and with the increase in severity of acne, an inverse relation between serum levels of vitamin D and body mass index was seen, but statistically significant relation was found only in the very severe cases of acne vulgaris.