Nonalcoholic Fatty Liver Disease, the Gut Microbiome, and Diet

被引：125

作者：

Mokhtari, Zeinab ^{[1
]}

Gibson, Deanna L. ^{[2
]}

Hekmatdoost, Azita ^{[1
,3
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, Dept Clin Nutr & Dietet, Tehran, Iran

[2] Univ British Columbia, Dept Biol, Okanagan Campus, Kelowna, BC, Canada

[3] Univ British Columbia, Dept Gastroenterol Hepatol & Nutr, Vancouver, BC, Canada

来源：

ADVANCES IN NUTRITION | 2017年 / 8卷 / 02期

关键词：

nonalcoholic fatty liver disease; gut microbiota; diet; NAFLD; NASH; probiotics; BUTYRATE-PRODUCING BACTERIA; FACTOR-KAPPA-B; DOUBLE-BLIND; HEPATIC STEATOSIS; RESISTANT STARCH; INDUCED OBESITY; RISK-FACTORS; RESVERATROL SUPPLEMENTATION; SYNBIOTIC SUPPLEMENTATION; INTESTINAL PERMEABILITY;

D O I：

10.3945/an.116.013151

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder in the world, yet the pathogenesis of the disease is not well elucidated. Due to the close anatomic and functional association between the intestinal lumen and the liver through the portal system, it is speculated that the gut microbiome may play a pivotal role in the pathogenesis of NAFLD. Furthermore, diet, which can modulate the gut microbiome and several metabolic pathways involved in NAFLD development, shows a potential tripartite relation between the gut, diet, and the liver. In this review, we summarize the current evidence that supports the association between NAFLD, the gut microbiome, and the role of diet.

引用

页码：240 / 252

页数：13

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