Synthesis of Biaryls and Aryl Ketones via Microwave-Assisted Decarboxylative Cross-Couplings

被引：73

作者：

Goossen, Lukas J. ^{[1
]}

Zimmermann, Bettina ^{[1
]}

Linder, Christophe ^{[1
]}

Rodriguez, Nuria ^{[1
]}

Lange, Paul P. ^{[1
]}

Hartung, Jens ^{[1
]}

机构：

[1] TU Kaiserslautern, FB Chem Organ Chem, D-67663 Kaiserslautern, Germany

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2009年 / 351卷 / 16期

关键词：

biaryls; copper; cross-coupling; microwave heating; palladium; CARBOXYLIC-ACIDS; AROMATIC CARBOXYLATES; HALIDES; PALLADATION; ARYLATION; CATALYSIS; BROMIDES;

D O I：

10.1002/adsc.200900337

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A protocol for the microwave-assisted decarboxylative cross-couplings of carboxylic acid salts with aryl halides has been developed that allows the synthesis of various biaryls and aryl ketones in high yields. After careful adaptation of the bimetallic catalyst system and reaction conditions, these mechanistically complex transformations can now be performed within only five minutes in concentrated solution in a sealed vessel. This greatly simplified reaction protocol is ideally suited for applications in parallel synthesis and drug discovery.

引用

页码：2667 / 2674

页数：8

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