A simple and efficient separation of the curcumins, the antiprotozoal constituents of Curcuma longa

被引：107

作者：

Rasmussen, HB

Christensen, SB

Kvist, LP

Karazmi, A

机构：

[1] Royal Danish Sch Pharm, Dept Med Chem, DK-2100 Copenhagen, Denmark

[2] Univ Copenhagen Hosp, Dept Clin Microbiol, Copenhagen, Denmark

来源：

PLANTA MEDICA | 2000年 / 66卷 / 04期

关键词：

D O I：

10.1055/s-2000-8533

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A simple and efficient method for the separation of the three phenolic diketones, curcumin 1, demethoxycurcumin 2, and bis-demethoxycurcumin 3, isolated from the rhizomes of Curcuma longa has been developed. The method is of general applicability for the separation of compounds containing acidic and chelating groups and is amenable to large scale separations. The curcumins 1-3 show moderate activity against Plasmodium falciparum (IC50: 3.5, 4.2 and 3.0 mu g/ml) and Leishmania major (IC50,: 7.8, 14.1 and 21.5 mu g/ml) respectively.

引用

页码：396 / 398

页数：3

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