Overexpression of chromatin assembly factor-1/p60 predicts biological behaviour of laryngeal carcinomas

被引：11

作者：

Mesolella, M. ^{[1
,2
]}

Iorio, B. ^{[1
,2
]}

Landi, M. ^{[1
,2
]}

Cimmino, M. ^{[1
,2
]}

Ilardi, G. ^{[3
]}

Iengo, M. ^{[1
,2
]}

Mascolo, M. ^{[3
]}

机构：

[1] Univ Naples Federico II, ENT Sect, Dept Neurosci, I-80138 Naples, Italy

[2] AOU Federico II, Via S Pansini 5, I-80131 Naples, Italy

[3] Univ Naples Federico II, Pathol Sect, Dept Adv Biomed Sci, Naples, Italy

来源：

ACTA OTORHINOLARYNGOLOGICA ITALICA | 2017年 / 37卷 / 01期

关键词：

CAF-1/p60; Prognostic factor; Laryngeal cancer; Carcinoma in situ; Dysplasia; Tumoural marker; FACTOR-I; DNA-REPLICATION; CLINICAL-VALUE; CAF-1; SUBUNIT; REPAIR; PROLIFERATION; MAINTENANCE; MARKER; ASF1;

D O I：

10.14639/0392-100X-867

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

This study analysed the immunohistochemical expression of the CAF-1/p60 protein in laryngeal cancers. CAF-1/p60 assumes an independent discriminative and prognostic value in laryngeal neoplasms; the presence of this protein in carcinoma in situ compared with laryngeal precancerous and larynx infiltrating tumours. We assessed the immunohistochemical expression of CAF-1/p60 in 30 cases of moderate and/or severe dysplasia, 30 cases of carcinoma in situ and 30 cases of laryngeal squamous cell carcinoma (LSCCs). CAF-1/p60 expression increased significantly according to the high index of neoplastic cellular replication; therefore, CAF-1/p60 was overexpressed in neoplastic cells and its moderate-severe expression is correlated with poorer prognosis compared to less expression. In conclusion, overexpression of the CAF-1/p60 protein is related to a risk of higher morbidity and mortality and is a reliable independent prognostic index of laryngeal carcinoma. CAF1-p60 protein overexpression can be used in cancer management as an indicator of malignant evolution, especially in carcinoma in situ.

引用

页码：17 / 24

页数：8

共 34 条

[1] WD repeats of the p48 subunit of chicken chromatin assembly factor-1 required for in vitro interaction with chicken histone deacetylase-2 [J].