The use of polymer heteronuclei for crystalline polymorph selection

被引：204
作者：
Lang, MD
Grzesiak, AL
Matzger, AJ [1 ]
机构：
[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Macromol Sci & Engn Program, Ann Arbor, MI 48109 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 50期
关键词：
D O I：
10.1021/ja0286526
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A method for the production of crystalline polymorphs from solution is described which utilizes a diverse set of polymer heteronuclei. Application to crystalline polymorph selection for the important pharmaceuticals acetaminophen and carbamazepine is demonstrated. This method provides a new paradigm for polymorph selection, where solvent and temperature conditions can be chosen on the basis of process considerations and the polymer heteronucleus can be varied for specific polymorph production. Copyright © 2002 American Chemical Society.
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收藏
页码：14834 / 14835
页数：2
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