Contemporary Antiplatelet Therapy and Clinical Outcomes of Japanese Patients With Acute Myocardial Infarction Results From the Prospective Japan Acute Myocardial Infarction Registry (JAMIR)

被引：25

作者：

Yasuda, Satoshi ^{[1
,22
]}

Honda, Satoshi ^{[1
,22
]}

Takegami, Misa ^{[2
,22
]}

Nishihira, Kensaku ^{[3
,22
]}

Kojima, Sunao ^{[4
,21
]}

Asaumi, Yasuhide ^{[1
,22
]}

Suzuki, Makoto ^{[5
]}

Kosuge, Masami ^{[6
,14
]}

Takahashi, Jun ^{[7
,12
]}

Sakata, Yasuhiko ^{[7
,12
]}

Takayama, Morimasa ^{[5
]}

Sumiyoshi, Tetsuya ^{[5
,13
]}

Ogawa, Hisao ^{[1
,22
]}

Kimura, Kazuo ^{[6
,14
]}

Takenaka, Takashi ^{[8
]}

Tomita, Hirofumi ^{[9
]}

Yokoyama, Hiroaki ^{[9
]}

Ito, Tomonori ^{[10
]}

Ishida, Masaru ^{[10
]}

Koeda, Yorihiko ^{[10
]}

Watanabe, Masafumi ^{[11
]}

Watanabe, Tetsu ^{[11
]}

Toshima, Taku ^{[11
]}

Shimokawa, Hiroaki ^{[12
]}

Hao, Kiyotaka ^{[12
]}

Takayama, Masamori ^{[5
,13
]}

Ebina, Toshiaki ^{[14
]}

Suzuki, Hiroshi ^{[15
]}

Maeda, Atsuo ^{[15
]}

Ito, Masaaki ^{[16
]}

Kurita, Tairo ^{[16
]}

Masuda, Jun ^{[16
]}

Tanigawa, Takashi ^{[17
]}

Higaki, Jitsuo ^{[18
]}

Nishimura, Kazuhisa ^{[3
,18
]}

Takahashi, Naohiko ^{[19
]}

Akioka, Hidefumi ^{[19
]}

Kawano, Kyoko ^{[6
,19
]}

Maemura, Koji ^{[20
]}

Koide, Yuji ^{[20
]}

Tsujita, Kenichi ^{[21
]}

Miyamoto, Yoshihiro ^{[22
]}

Nakajima, Hiroshi ^{[23
]}

Yamaguchi, Kenji ^{[24
]}

Makino, Takao ^{[25
]}

Kannno, Daitarou ^{[26
]}

Omoto, Yasuhiro ^{[27
]}

Otta, Daisuke ^{[28
]}

Sato, Toshiya ^{[5
,29
]}

Sato, Naoki ^{[30
]}

机构：

[1] Natl Cerebral & Cardiovasc Ctr, Dept Cardiovasc Med, 5-7-1 Fujishiro Dai, Suita, Osaka 5658565, Japan

[2] Natl Cerebral & Cardiovasc Ctr, Dept Prevent Med & Epidemiol Informat, Suita, Osaka, Japan

[3] Miyazaki Med Assoc Hosp, Dept Cardiovasc Med, Miyazaki, Japan

[4] Kawasaki Med Sch, Dept Gen Internal Med 3, Okayama, Japan

[5] Sakakibara Heart Inst, Dept Cardiol, Fuchu, Tokyo, Japan

[6] Yokohama City Univ, Med Ctr, Dept Cardiovasc Med, Yokohama, Kanagawa, Japan

[7] Tohoku Univ, Dept Cardiovasc Med, Sendai, Miyagi, Japan

[8] Hokkaido Med Ctr, Sapporo, Hokkaido, Japan

[9] Hirosaki Univ, Hirosaki, Aomori, Japan

[10] Iwate Med Univ, Morioka, Iwate, Japan

[11] Yamagata Univ, Yamagata, Japan

[12] Tohoku Univ, Sendai, Miyagi, Japan

[13] Sakakibara Heart Inst, Fuchu, Tokyo, Japan

[14] Yokohama City Univ Med, Yokohama, Kanagawa, Japan

[15] Showa Univ, Fujigaoka Hosp, Yokohama, Kanagawa, Japan

[16] Mie Univ Hosp, Tsu, Mie, Japan

[17] Matsuzaka Cent Gen Hosp, Matsuzaka, Japan

[18] Ehime Univ Hosp, Toon, Japan

[19] Oita Univ, Oita, Japan

[20] Nagasaki Univ, Nagasaki, Japan

[21] Kumamoto Univ, Kumamoto, Japan

[22] Natl Cerebral & Cardiovasc Ctr, Suita, Osaka, Japan

[23] Nagasaki Harbor Med Ctr, Nagasaki, Japan

[24] Isahaya Gen Hosp, Isahaya, Japan

[25] Sapporo City Gen Hosp, Sapporo, Hokkaido, Japan

[26] Sapporo Cardiovasc Clin, Sapporo, Hokkaido, Japan

[27] Teine Keijinkai Hosp, Sapporo, Hokkaido, Japan

[28] Hokkaido Cardiol Hosp, Sapporo, Hokkaido, Japan

[29] Sapporo Kosei Gen Hosp, Sapporo, Hokkaido, Japan

[30] Nippon Med Sch, Musashi Kosugi Hosp, Tokyo, Japan

[31] Ayase Heart Hosp, Ayase, Kanagawa, Japan

[32] Tokyo Metropolitan Hiroo Gen Hosp, Tokyo, Japan

[33] Nippon Med Coll Hosp, Tokyo, Japan

[34] Tokyo Saiseikai Cent Hosp, Tokyo, Japan

[35] Tokyo Med Ctr, Tokyo, Japan

[36] St Lukes Int Hosp, Tokyo, Japan

[37] Edogawa Hosp, Tokyo, Japan

[38] Kyorin Univ Hosp, Mitaka, Tokyo, Japan

[39] Nihon Univ, Itabashi Hosp, Tokyo, Japan

[40] Toho Univ, Omori Med Ctr, Tokyo, Japan

[41] Mitsui Mem Hosp, Tokyo, Japan

[42] Tokyo Metropolitan Tama Med Ctr, Tokyo, Japan

[43] Disaster Med Ctr, Tachikawa, Tokyo, Japan

[44] Musashino Red Cross Hosp, Musashino, Tokyo, Japan

[45] NTT Med Ctr, Tokyo, Japan

[46] Oume Municipal Gen Hosp, Ome, Japan

[47] Oghikubo Hosp, Tokyo, Japan

[48] Teikyo Univ Hosp, Tokyo, Japan

[49] Fratern Mem Hosp, Tokyo, Japan

[50] Jikei Univ Hosp, Tokyo, Japan

来源：

CIRCULATION JOURNAL | 2019年 / 83卷 / 08期

关键词：

Acute myocardial infarction; Antiplatelet therapy; Bleeding events; Prasugrel; PERCUTANEOUS CORONARY INTERVENTION; TREATED PATIENTS; ARTERY-DISEASE; FOCUSED UPDATE; CLOPIDOGREL; PRASUGREL; TICAGRELOR; PHARMACOKINETICS; PHARMACODYNAMICS; POLYMORPHISMS;

D O I：

10.1253/circj.CJ-19-0145

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Antiplatelet therapy is the corner stone of treatment following acute myocardial infarction (AMI). Prasugrel, a new and potent antiplatelet agent, was recently introduced to clinical practice. We compared the clinical outcomes of patients with AMI treated with prasugrel with those treated with clopidogrel in real-world clinical practice in Japan. Methods and Results: The Japan AMI Registry (JAMIR) is a multicenter, nationwide, prospective registry enrolling patients with AMI from 50 institutes. Between December 2015 and May 2017, a total of 3,411 patients were enrolled. Among them, 3,069 patients were treated with either prasugrel (n=2,607) or clopidogrel (n=462) during hospitalization. Median follow-up period was 12 months. Prasugrel-treated patients were predominantly male, younger, more often showed ST-elevation AMI, and had fewer comorbidities. After adjustment using inverse probability of treatment weighting, the primary endpoint, defined as a composite of cardiovascular death, non-fatal MI and non-fatal stroke, was comparable between the prasugrel and clopidogrel groups (adjusted hazard ratio [HR] 1.07, 95% confidence interval [CI] 0.67-1.72), whereas the risk of major bleeding (BARC type 3 or 5 bleeding) was significantly lower in the prasugrel group (adjusted HR 0.62, 95% CI 0.39-0.99). Conclusions: The present real-world database of the JAMIR demonstrated that the potent P2Y12-inhibitor prasugrel showed comparable rates of 1-year ischemic events to clopidogrel, but the risk of bleeding was lower with prasugrel than with clopidogrel.

引用

页码：1633 / +

页数：22

共 32 条

[1] Variability in individual responsiveness to clopidogrel - Clinical implications, management, and future perspectives [J].

Angiolillo, Dominick J. ;

Fernandez-Ortiz, Antonio ;

Bernardo, Esther ;

Alfonso, Fernando ;

Macaya, Carlos ;

Bass, Theodore A. ;

Costa, Marco A. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 49 (14) :1505-1516

[2] Ticagrelor Use in Acute Myocardial Infarction: Insights From the National Cardiovascular Data Registry [J].

Basra, Sukhdeep S. ;

Wang, Tracy Y. ;

Simon, Dajuanicia N. ;

Chiswell, Karen ;

Virani, Salim S. ;

Alam, Mahboob ;

Nambi, Vijay ;

Denktas, Ali E. ;

Deswal, Anita ;

Bozkurt, Biykem ;

Ballantyne, Christie M. ;

Peterson, Eric D. ;

Jneid, Hani .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2018, 7 (12)

[3] Adjusted survival curves with inverse probability weights [J].

Cole, SR ;

Hernán, MA .

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, 2004, 75 (01) :45-49

[4] Clinical end points in coronary stent trials - A case for standardized definitions [J].

Cutlip, Donald E. ;

Windecker, Stephan ;

Mehran, Roxana ;

Boam, Ashley ;

Cohen, David J. ;

van Es, Gerrit-Anne ;

Steg, P. Gabriel ;

Morel, Marie-angele ;

Mauri, Laura ;

Vranckx, Pascal ;

McFadden, Eugene ;

Lansky, Alexandra ;

Hamon, Martial ;

Krucoff, Mitchell W. ;

Serruys, Patrick W. .

CIRCULATION, 2007, 115 (17) :2344-2351

[5] Treatment Patterns and Outcomes in Patients Undergoing Percutaneous Coronary Intervention Treated With Prasugrel or Clopidogrel (from the Swedish Coronary Angiography and Angioplasty Registry [SCAAR]) [J].

Damman, Peter ;

Varenhorst, Christoph ;

Koul, Sasha ;

Eriksson, Peter ;

Erlinge, David ;

Lagerqvist, Bo ;

James, Stefan K. .

AMERICAN JOURNAL OF CARDIOLOGY, 2014, 113 (01) :64-69

[6] Ticagrelor vs. Clopidogrel in Japanese, Korean and Taiwanese Patients With Acute Coronary Syndrome - Randomized, Double-Blind, Phase III PHILO Study - [J].

Goto, Shinya ;

Huang, Chien-Hua ;

Park, Seung-Jung ;

Emanuelsson, Hakan ;

Kimura, Takeshi .

CIRCULATION JOURNAL, 2015, 79 (11) :2452-+

[7] The effect of CYP2C19 gene polymorphisms on the pharmacokinetics and pharmacodynamics of prasugrel 5-mg, prasugrel 10-mg and clopidogrel 75-mg in patients with coronary artery disease [J].

Gurbel, Paul A. ;

Bergmeijer, Thomas O. ;

Tantry, Udaya S. ;

ten Berg, Jurrien M. ;

Angiolillo, Dominick J. ;

James, Stefan ;

Lindahl, Tomas L. ;

Svensson, Peter ;

Jakubowski, Joseph A. ;

Brown, Patricia B. ;

Duvvuru, Suman ;

Sundseth, Scott ;

Walker, Joseph R. ;

Small, David ;

Moser, Brian A. ;

Winters, Kenneth J. ;

Erlinge, David .

THROMBOSIS AND HAEMOSTASIS, 2014, 112 (03) :589-597

[8] An overview of the objectives of and the approaches to propensity score analyses [J].

Heinze, Georg ;

Jueni, Peter .

EUROPEAN HEART JOURNAL, 2011, 32 (14) :1704-1708

[9] Rationale, Design, and Baseline Characteristics of the Prospective Japan Acute Myocardial Infarction Registry (JAMIR) [J].

Honda, Satoshi ;

Nishihira, Kensaku ;

Kojima, Sunao ;

Takegami, Misa ;

Asaumi, Yasuhide ;

Suzuki, Makoto ;

Kosuge, Masami ;

Takahashi, Jun ;

Sakata, Yasuhiko ;

Takayama, Morimasa ;

Sumiyoshi, Tetsuya ;

Ogawa, Hisao ;

Kimura, Kazuo ;

Yasuda, Satoshi ;

Takenaka, Takashi ;

Tomita, Hirofumi ;

Yokoyama, Hiroaki ;

Ito, Tomonori ;

Ishida, Masaru ;

Koeda, Yorihiko ;

Watanabe, Masafumi ;

Watanabe, Tetsu ;

Toshima, Taku ;

Shimokawa, Hiroaki ;

Hao, Kiyotaka ;

Ebina, Toshiaki ;

Suzuki, Hiroshi ;

Maeda, Atsuo ;

Ito, Masaaki ;

Kurita, Tairo ;

Masuda, Jun ;

Tanigawa, Takashi ;

Higaki, Jitsuo ;

Nishimura, Kazuhisa ;

Takahashi, Naohiko ;

Akioka, Hidefumi ;

Kawano, Kyoko ;

Maemura, Koji ;

Koide, Yuji ;

Kojima, Sunao ;

Tsujita, Kenichi ;

Miyamoto, Yoshihiro ;

Nakao, Yoko ;

Nakajima, Hiroshi ;

Yamaguchi, Kenji ;

Makino, Takao ;

Kanno, Daitarou ;

Omoto, Yasuhiro ;

Hotta, Daisuke ;

Sato, Toshiya .

CARDIOVASCULAR DRUGS AND THERAPY, 2019, 33 (01) :97-103

[10] 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation [J].

Ibanez, Borja ;

James, Stefan ;

Agewall, Stefan ;

Antunes, Manuel J. ;

Bucciarelli-Ducci, Chiara ;

Bueno, Hector ;

Caforio, Alida L. P. ;

Crea, Filippo ;

Goudevenos, John A. ;

Halvorsen, Sigrun ;

Hindricks, Gerhard ;

Kastrati, Adnan ;

Lenzen, Mattie J. ;

Prescott, Eva ;

Roffi, Marco ;

Valgimigli, Marco ;

Varenhorst, Christoph ;

Vranckx, Pascal ;

Widimsky, Petr .

KARDIOLOGIA POLSKA, 2018, 76 (02) :229-313

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