On Parallel Streams through the Mouse Dorsal Lateral Geniculate Nucleus

被引:23
作者
Denman, Daniel J. [1 ]
Contreras, Diego [2 ]
机构
[1] Allen Inst Brain Sci, Seattle, WA USA
[2] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA
来源
FRONTIERS IN NEURAL CIRCUITS | 2016年 / 10卷
基金
美国国家卫生研究院;
关键词
LGN; parallel processing; mouse vision; cell types; mouse models; RECEPTIVE-FIELD PROPERTIES; RETINAL GANGLION-CELLS; PRIMARY VISUAL-CORTEX; MONKEY AOTUS-TRIVIRGATUS; RESPONSE PROPERTIES; OPTIC TRACT; X-CELL; Y-CELL; CONDUCTION-VELOCITY; SPATIAL SUMMATION;
D O I
10.3389/fncir.2016.00020
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The mouse visual system is an emerging model for the study of cortical and thalamic circuit function. To maximize the usefulness of this model system, it is important to analyze the similarities and differences between the organization of all levels of the murid visual system with other, better studied systems (e.g., non-human primates and the domestic cat). While the understanding of mouse retina and cortex has expanded rapidly, less is known about mouse dorsal lateral geniculate nucleus (dLGN). Here, we study whether parallel processing streams exist in mouse dLGN. We use a battery of stimuli that have been previously shown to successfully distinguish parallel streams in other species: electrical stimulation of the optic chiasm, contrast-reversing stationary gratings at varying spatial phase, drifting sinusoidal gratings, dense noise for receptive field reconstruction, and frozen contrast-modulating noise. As in the optic nerves of domestic cats and non-human primates, we find evidence for multiple conduction velocity groups after optic chiasm stimulation. As in so-called "visual mammals", we find a subpopulation of mouse dLGN cells showing non-linear spatial summation. However, differences in stimulus selectivity and sensitivity do not provide sufficient basis for identification of clearly distinct classes of relay cells. Nevertheless, consistent with presumptively homologous status of dLGNs of all mammals, there are substantial similarities between response properties of mouse dLGN neurons and those of cats and primates.
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页数:14
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