Clinical, endoscopic and histopathological evaluation of the efficacy of budesonide in the treatment of inflammatory bowel disease in dogs

被引：4
作者：
Rychlik, A. [1 ]
Kolodziejska-Sawerska, A. [1 ]
Novicki, M. [1 ]
Szweda, M. [1 ]
机构：
[1] Univ Warmia & Mazury, Dept Clin Diagnost, Fac Vet Med, Oczapowskiego 14, PL-10719 Olsztyn, Poland
来源：
POLISH JOURNAL OF VETERINARY SCIENCES | 2016年 / 19卷 / 01期
关键词：
IBD; budesonide; dogs; CIBDAI; endoscopy; ACTIVE CROHNS-DISEASE; ORAL BUDESONIDE; DIAGNOSIS; PREDNISOLONE;
D O I：
10.1515/pjvs-2016-0020
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
This study evaluates the efficacy of budesonide in the treatment of inflammatory bowel disease (IBD) in dogs based on the results of clinical, endoscopic and histopathological examinations. The severity of clinical symptoms was assessed based on CIBDAI scores, and macroscopic and histopathological changes were described in accordance with the recommendations of the WSAVA Gastrointestinal Standardization Group for 2008. The results of the experiment revealed that budesonide does not offer effective treatment for canine IBD. The tested drug failed to alleviate the clinical symptoms of disease, lower CIBDAI scores, or improve the macroscopic appearance of intestinal mucosa. The effectiveness of budesonide was most highly evaluated in the histopathological picture of duodenal, jejunal and colonic mucosa.
引用
收藏
页码：159 / 164
页数：6
相关论文
共 18 条
  • [1] Budesonide: Teaching an Old Dog New Tricks for Inflammatory Bowel Disease Treatment
    Angelucci, Erika
    Malesci, Alberto
    Danese, Silvio
    [J]. CURRENT MEDICINAL CHEMISTRY, 2008, 15 (24) : 2527 - 2535
  • [2] Budesonide versus prednisone in the treatment of active Crohn's disease
    Bar-Meir, S
    Chowers, Y
    Lavy, A
    Abramovitch, D
    Sternberg, A
    Leichtmann, G
    Reshef, R
    Odes, S
    Moshkovitz, M
    Bruck, R
    Eliakim, R
    Maoz, E
    Mittmann, U
    [J]. GASTROENTEROLOGY, 1998, 115 (04) : 835 - 840
  • [3] Oral budesonide is as effective as oral prednisolone in active Crohn's disease
    Campieri, M
    Ferguson, A
    Doe, W
    Persson, T
    Nilsson, LG
    Malchow, H
    Prantera, C
    Mani, V
    OMorain, C
    Selby, W
    Pallone, F
    diPietralata, MM
    Sjodahl, R
    Florin, T
    Smith, P
    Bianchi, P
    Lofberg, R
    Rutgeerts, P
    Smallwood, R
    Lamers, HW
    TasmanJones, C
    Hunter, JO
    Hodgson, H
    Danielsson, A
    Lee, FI
    Piacitelli, G
    Giovanni, S
    Ellis, A
    Weir, DG
    [J]. GUT, 1997, 41 (02) : 209 - 214
  • [4] Canine inflammatory bowel disease: retrospective analysis of diagnosis and outcome in 80 cases (1995-2002)
    Craven, M
    Simpson, JW
    Ridyard, AE
    Chandler, ML
    [J]. JOURNAL OF SMALL ANIMAL PRACTICE, 2004, 45 (07) : 336 - 342
  • [5] Histopathological standards for the diagnosis of gastrointestinal inflammation in endoscopic biopsy samples from the dog and cat: A report from the world small animal veterinary association gastrointestinal standardization group
    Day, M. J.
    Bilzert, T.
    Mansell, J.
    Wilcock, B.
    Hall, E. J.
    Jergens, A.
    Minami, T.
    Willard, M.
    Washabau, R.
    [J]. JOURNAL OF COMPARATIVE PATHOLOGY, 2008, 138 : S1 - S40
  • [6] Gross V, 1996, EUR J GASTROEN HEPAT, V8, P905
  • [7] Jergens AE, 2003, J VET INTERN MED, V17, P291, DOI 10.1892/0891-6640(2003)017<0291:ASIFDA>2.3.CO
  • [8] 2
  • [9] Jergens Albert E, 2012, Front Biosci (Elite Ed), V4, P1404
  • [10] Treatment of inflammatory bowel disease (IBD) in dogs and cats
    Malewska, K.
    Rychlik, A.
    Nieradka, R.
    Kander, M.
    [J]. POLISH JOURNAL OF VETERINARY SCIENCES, 2011, 14 (01): : 165 - 170
12