The downregulation of asparagine synthetase expression can increase the sensitivity of cells resistant to L-asparaginase

被引:29
|
作者
Li, B. S. [1 ]
Gu, L. J.
Luo, C. Y.
Li, W. S.
Jiang, L. M.
Shen, S. H.
Jiang, H.
Shen, S. H.
Zhang, B.
Chen, J.
Xue, H. L.
Tang, J. Y.
机构
[1] Shanghai Jiao Tong Univ, Sch Med, Dept Hematol Oncol, Shanghai Childrens Med Ctr,Xin Hua Hosp, Shanghai 200030, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Med, Dept Pediat Surg, Xin Hua Hosp, Shanghai 200030, Peoples R China
[3] Shanghai Jiao Tong Univ, Sch Med, Lab Diagnost Ctr, Shanghai Childrens Med Ctr,Xin Hua Hosp, Shanghai 200030, Peoples R China
关键词
D O I
10.1038/sj.leu.2404423
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:2199 / 2201
页数:4
相关论文
共 50 条
  • [31] MEASUREMENT OF SERUM L-ASPARAGINE IN THE PRESENCE OF L-ASPARAGINASE REQUIRES THE PRESENCE OF AN L-ASPARAGINASE INHIBITOR
    ASSELIN, BL
    LORENSON, MY
    WHITIN, JC
    COPPOLA, DJ
    KENDE, AS
    BLAKLEY, RL
    COHEN, HJ
    CANCER RESEARCH, 1991, 51 (24) : 6568 - 6573
  • [32] Up-regulation of asparagine synthetase expression is not linked to the clinical response to L-asparaginase in pediatric acute lymphoblastic leukemia
    Appel, Inge M.
    den Boer, Monique L.
    Meijerink, Jules P. P.
    Veerman, Anjo J. P.
    Reniers, Nathalie C. M.
    Pieters, Rob
    BLOOD, 2006, 107 (11) : 4244 - 4249
  • [33] EFFECTS OF ASPARAGINE SYNTHETASE INHIBITORS ON ASPARAGINASE RESISTANT TUMORS
    UREN, JR
    CHANG, PK
    HANDSCHUMACHER, RE
    BIOCHEMICAL PHARMACOLOGY, 1977, 26 (15) : 1405 - 1410
  • [34] ASPARAGINE SYNTHETASE IN ASPARAGINASE RESISTANT AND SUSCEPTIBLE MOUSE LYMPHOMAS
    PRAGER, MD
    BACHYNSKY, N
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1968, 31 (01) : 43 - +
  • [35] SENSITIVITY OF FIBROBLAST CELLS TO APOPTOSIS INDUCED BY L-ASPARAGINASE
    BUSSOLATI, O
    BELLETTI, S
    GATTI, R
    ORLANDINI, G
    UGGERI, J
    DALLASTA, V
    GAZZOLA, GC
    FASEB JOURNAL, 1995, 9 (03): : A419 - A419
  • [36] NUTRITIONAL REQUIREMENTS OF HUMAN LEUKEMIC CELLS - ASPARAGINE REQUIREMENTS AND EFFECT OF L-ASPARAGINASE
    LAZARUS, H
    MCCOY, TA
    FARBER, S
    BARELL, EF
    FOLEY, GE
    EXPERIMENTAL CELL RESEARCH, 1969, 57 (01) : 134 - &
  • [37] INVIVO EFFECTS OF INTRAPERITONEALLY INJECTED L-ASPARAGINASE SOLUTION AND L-ASPARAGINASE IMMOBILIZED WITHIN SEMIPERMEABLE NYLON MICRCAPSULES WITH EMPHASIS ON BLOOD L-ASPARAGINASE, BODY L-ASPARAGINASE, AND PLASMA L-ASPARAGINE LEVELS
    CHONG, EDS
    CHANG, TMS
    ENZYME, 1974, 18 (3-4) : 218 - 239
  • [38] The inhibition of glutamine synthetase sensitizes human sarcoma cells to L-asparaginase
    Tardito, S.
    Uggeri, J.
    Bozzetti, C.
    Bianchi, M. G.
    Rotoli, B. M.
    Franchi-Gazzola, R.
    Gazzola, G. C.
    Gatti, R.
    Bussolati, O.
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2007, 60 (05) : 751 - 758
  • [39] The inhibition of glutamine synthetase sensitizes human sarcoma cells to l-asparaginase
    S. Tardito
    J. Uggeri
    C. Bozzetti
    M. G. Bianchi
    B. M. Rotoli
    R. Franchi-Gazzola
    G. C. Gazzola
    R. Gatti
    O. Bussolati
    Cancer Chemotherapy and Pharmacology, 2007, 60 : 751 - 758
  • [40] A sulfoximine-based inhibitor of human asparagine synthetase kills L-asparaginase-resistant leukemia cells
    Ikeuchi, Hideyuki
    Ahn, Yong-Mo
    Otokawa, Takuya
    Watanabe, Bunta
    Hegazy, Lamees
    Hiratake, Jun
    Richards, Nigel G. J.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2012, 20 (19) : 5915 - 5927