Condensation Reactions To Form Oxazoline-Substituted Potassium Organotrifluoroborates

被引：38

作者：

Molander, Gary A. ^{[1
]}

Febo-Ayala, Wilma ^{[1
]}

Jean-Gerard, Ludivine ^{[1
]}

机构：

[1] Univ Penn, Dept Chem, Roy & Diana Vagelos Labs, Philadelphia, PA 19104 USA

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 17期

关键词：

ASYMMETRIC ALDOL REACTION; BORONIC ACIDS;

D O I：

10.1021/ol901395c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A library of oxazoline-substituted potassium organotrifluoroborates was prepared via the condensation of various potassium formyl-substituted aryl- and heteroaryltrifluoroborates with tosylmethyl isocyanide under basic conditions. The efficient Suzuki-Miyaura cross-coupling of products thus formed to various aryl bromides was achieved in good yields. The method allows the facile preparation of oxazole-containing triaromatic products In two steps from simple potassium formyl-substituted aryl- or heteroaryltrifluoroborates.

引用

页码：3830 / 3833

页数：4

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