TNF-α contributes to axonal sprouting and functional recovery following traumatic brain injury

被引：56

作者：

Oshima, Taku ^{[2
,3
]}

Lee, Sachiko ^{[1
]}

Sato, Akinobu ^{[1
]}

Oda, Shigeto ^{[3
]}

Hirasawa, Hiroyuki ^{[3
]}

Yamashita, Toshihide ^{[1
,2
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Mol Neurosci, Suita, Osaka 5650871, Japan

[2] Chiba Univ, Grad Sch Med, Dept Neurobiol, Chiba, Japan

[3] Chiba Univ, Grad Sch Med, Dept Emergency & Crit Care Med, Chiba, Japan

来源：

BRAIN RESEARCH | 2009年 / 1290卷

关键词：

Axon; Brain injury; Motor function; Regeneration; TNF-alpha; TUMOR-NECROSIS-FACTOR; CLOSED-HEAD INJURY; RAT-BRAIN; MICE LACKING; EXPRESSION; RECEPTOR; PLASTICITY; ELEVATION; RESPONSES; PLASMA;

D O I：

10.1016/j.brainres.2009.07.022

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In response to a central nervous system (CNS) injury, microglia and astrocytes release tumor necrosis factor-alpha (TNF-alpha). This proinflammatory cytokine has been implicated in both neuronal cell death and survival. Here, we show that TNF-alpha is involved in the recovery of neuromotor function following traumatic brain injury. Composite neuroscore and accel rotarod were employed to measure neuromotor function. TNF-alpha-deficient (TNF-alpha(-/-)) mice showed no improvement in their locomotor function up to 28 days following controlled cortical impact brain injury. Although collateral sprouting of the unlesioned corticospinal tract, as assessed by retrograde biotin dextran amine labeling, at the cervical spinal cord was observed following injury in the wild-type mice, such changes were not induced in the TNF-alpha(-/-) mice at 4 weeks after injury. These results provide evidence that TNF-alpha is involved in neuroanatomical plasticity and functional recovery following CNS injury. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：102 / 110

页数：9

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