Isolation and biosynthesis of an unsaturated fatty acid with unusual methylation pattern from a coral-associated bacterium Microbulbifer sp.

被引：10

作者：

Sharma, Amit Raj ^{[1
,2
]}

Harunari, Enjuro ^{[1
,2
]}

Zhou, Tao ^{[1
,2
]}

Trianto, Agus ^{[3
]}

Igarashi, Yasuhiro ^{[1
,2
]}

机构：

[1] Toyama Prefectural Univ, Biotechnol Res Ctr, 5180 Kurokawa, Imizu, Toyama 9390398, Japan

[2] Toyama Prefectural Univ, Dept Biotechnol, 5180 Kurokawa, Imizu, Toyama 9390398, Japan

[3] Diponegoro Univ, Fac Fisheries & Marine Sci, Tembalang Campus, Semarang 50275, Central Java, Indonesia

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 15卷

关键词：

biosynthesis; fatty acid; marine bacteria; methylation; Microbulbifer; SP NOV; MARINE; PSEUDOALTEROMONE; METHIONINE; SEA;

D O I：

10.3762/bjoc.15.225

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(2Z,4E)-3-Methyl-2,4-decadienoic acid (1) was identified as a major metabolite from a culture extract of a marine bacterium Microbulbifer which was collected from a stony coral Porites sp. NMR-based spectroscopic analysis revealed that 1 is an unsaturated fatty acid in which a methyl group is located in an uncommon position as a natural product. Feeding experiments of C-13-labeled precursors clarified that L-methionine-derived methylation takes place at the carbon which is derived from the carbonyl carbon of acetate. Compound 1 showed weak growth inhibition against Saccharomyces cerevisiae.

引用

页码：2327 / 2332

页数：6

共 22 条

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