Magnetic Field Effect in the Reaction of Recombination of Nitric Oxide and Superoxide Anion

被引：15

作者：

Karogodina, Tatiana Yu ^{[1
]}

Sergeeva, Svetlana V. ^{[2
]}

Stass, Dmitri V. ^{[1
,3
]}

机构：

[1] SB RAS, Inst Chem Kinet & Combust, Novosibirsk 630090, Russia

[2] SB RAS, Inst Cytol & Genet, Novosibirsk 630090, Russia

[3] Novosibirsk State Univ, Novosibirsk 630090, Russia

来源：

APPLIED MAGNETIC RESONANCE | 2009年 / 36卷 / 2-4期

关键词：

ETHANOLAMINE AMMONIA-LYASE; RADICAL-PAIR; HORSERADISH-PEROXIDASE; ENZYMATIC PHOSPHORYLATION; DIHYDRORHODAMINE; 123; ELECTRON-SPIN; IRON OVERLOAD; PEROXYNITRITE; MECHANISM; EXPOSURE;

D O I：

10.1007/s00723-009-0018-2

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

Using a static magnetic field, we observed an important biological radical, nitric oxide, in solution by a spin-sensitive technique. Decomposition of 3-morpholinosydnonimine (SIN-1) in aqueous solution produces a radical pair consisting of nitric oxide and the superoxide anion which recombine to form peroxynitrite. The creation of this radical pair provides a favorable setting for the observation of magnetic field effects. Magnetic field effect of (1.8 +/- A 0.5)% on the yield of recombination was observed in a relatively high field of 4.7 T over the sampling of 96 samples. The effect is limited by extremely fast relaxation of nitric oxide in liquids due to unquenched orbital angular momentum, and develops in f-pairs via the Delta g mechanism. Magnetic field effect due to a radical pair involving nitric oxide in a biological system would require either rather strong magnetic fields in the tesla range or an internal enhancer of magnetic field.

引用

页码：195 / 208

页数：14

共 67 条

[1] Superoxide and nitric oxide in pathological conditions associated with iron overload. The effects of antioxidants and chelators [J].

Afanas'ev, IB .

CURRENT MEDICINAL CHEMISTRY, 2005, 12 (23) :2731-2739

[2] Magnetic spin effects in enzymatic reactions: Radical oxidation of NADH by horseradish peroxidase [J].

Afanasyeva, Maria S. ;

Taraban, Marc B. ;

Purtov, Peter A. ;

Leshina, Tatyana V. ;

Grissom, Charles B. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (26) :8651-8658

[3]

Atkins P.W., 1967, Structure of Inorganic Radicals : An Application of Electron Spin Resonance to the study of Molecular Structure

[4] MAGNETIC RESONANCE ABSORPTION IN NITRIC OXIDE [J].

BERINGER, R ;

CASTLE, JG .

PHYSICAL REVIEW, 1950, 78 (05) :581-586

[5] ENDOR STUDY OF X-IRRADIATED SINGLE CRYSTALS OF ICE [J].

BOX, HC ;

BUDZINSK.EE ;

LILGA, T ;

FREUND, HG .

JOURNAL OF CHEMICAL PHYSICS, 1970, 53 (03) :1059-&

[6] Magnetic fields and radical reactions: recent developments and their role in nature [J].

Brocklehurst, B .

CHEMICAL SOCIETY REVIEWS, 2002, 31 (05) :301-311

[7] L-UNCOUPLING EFFECTS ON ELECTRON-PARAMAGNETIC-RESONANCE SPECTRA OF N14O16 AND N15O16 [J].

BROWN, RL ;

RADFORD, HE .

PHYSICAL REVIEW, 1966, 147 (01) :6-&

[8] Magnesium isotope effects in enzymatic phosphorylation [J].

Buchachenko, Anatoly L. ;

Kouznetsov, Dmitry A. ;

Breslavskaya, Natalia N. ;

Orlova, Marina A. .

JOURNAL OF PHYSICAL CHEMISTRY B, 2008, 112 (08) :2548-2556

[9] On the magnetic field and isotope effects in enzymatic phosphorylation [J].

Buchachenko, Anatoly L. ;

Lukzen, Nikita N. ;

Pedersen, J. Boiden .

CHEMICAL PHYSICS LETTERS, 2007, 434 (1-3) :139-143

[10] Activity increase of horseradish peroxidase in the presence of magnetic particles [J].

Chalkias, Nikolaos G. ;

Kahawong, Patarawan ;

Giannelis, Emmanuel P. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (10) :2910-2911

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