6-acylamino-penam derivatives: Synthesis and inhibition of cathepsins B, L, K, and S

被引：10

作者：

Zhou, NE ^{[1
]}

Kaleta, J ^{[1
]}

Purisima, E ^{[1
]}

Menard, R ^{[1
]}

Micetich, RG ^{[1
]}

Singh, R ^{[1
]}

机构：

[1] Natl Res Council Canada, Biotechnol Res Inst, Montreal, PQ H4P 2R2, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 23期

关键词：

D O I：

10.1016/S0960-894X(02)00766-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of a new series of 6-acylamino penam derivatives and their inhibition of cysteine proteases cathepsins B, L, K, and S is described. The 6-acylamino-penam sulfone compounds showed excellent cathepsin L, K, and S inhibition activity with IC50 values in the nanomolar and subnanomolar range. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3417 / 3419

页数：3

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