Spectroscopic, thermal, catalytic and biological studies of Cu(II) azo dye complexes

被引:31
作者
El-Sonbati, A. Z. [1 ]
Diab, M. A. [1 ]
El-Bindary, A. A. [1 ]
Shoair, A. F. [1 ]
Hussein, M. A. [2 ]
El-Boz, R. A. [1 ]
机构
[1] Damietta Univ, Dept Chem, Fac Sci, Dumyat, Egypt
[2] Port Said Univ, Dept Chem, Fac Sci, Port Said, Egypt
关键词
Azo compound; Cu(II) complexes; DNA binding; Biological activity; Thermal analysis; COPPER(II)-CATALYZED AEROBIC OXIDATION; MIXED-LIGAND COMPLEXES; PRIMARY ALCOHOLS; SUPRAMOLECULAR STRUCTURE; ANTIMICROBIAL ACTIVITY; OPTICAL-PROPERTIES; MOLECULAR DOCKING; DNA-BINDING; DERIVATIVES; COBALT(II);
D O I
10.1016/j.molstruc.2017.03.082
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
New complexes of copper(II) with azo compounds of 5-amino-2-(aryl diazenyl)phenol (HLn) are prepared and investigated by elemental analyses, molar conductance, IR, H-1 NMR, UV-Visible, mass, ESR spectra, magnetic susceptibility measurements and thermal analyses. The complexes have a square planar structure and general formula [Cu(L-n)(OAc)]H2O. Study the catalytic activities of Cu(II) complexes toward oxidation of benzyl alcohol derivatives to carbonyl compounds were tested using H2O2 as the oxidant. The intrinsic binding constants (K-b) of the ligands (HLn) and Cu(II) complexes (1-4) with CT-DNA are determined. The formed compounds have been tested for biological activity of antioxidants, antibacterial against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria and yeast Candida albicans. Antibiotic (Ampicillin) and antifungal against (Colitrimazole) and cytotoxic compounds HL1, HL2, HL3 and complex (1) showed moderate to good activity against S. aureus, E. coli and Candida albicans, and also to be moderate on antioxidants and toxic substances. Molecular docking is used to predict the binding between the ligands with the receptor of breast cancer (2a91). (C) 2017 Elsevier B.V. All rights reserved.
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页码:186 / 203
页数:18
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