Efficient synthesis, and antitumor and antioxidant activities of polyhydroxybenzophenone

被引：2

作者：

Zhou, Bei-Dou ^{[1
,2
,3
]}

Li, Jia-Li ^{[1
,2
]}

Ruan, Zhi-Peng ^{[1
,2
]}

Xu, Gui-Fen ^{[1
,2
]}

Fang, Yuan-Yuan ^{[1
,2
]}

Lin, Jian ^{[1
,2
]}

Zhang, Xiao-Ling ^{[4
]}

Hu, Dong-Bao ^{[5
]}

机构：

[1] Putian Univ, Sch Pharm & Med Technol, Putian 351100, Peoples R China

[2] Fujian Prov Univ, Putian Univ, Key Lab Pharmaceut Anal & Lab Med, Putian 351100, Peoples R China

[3] Fujian Tianquan Pharmaceut Co Ltd, Longyan 364000, Peoples R China

[4] Fujian Med Univ, Sch Pharm, Fujian Key Lab Drug Target Discovery & Struct & F, Fuzhou 350108, Peoples R China

[5] Yuxi Normal Univ, Sch Chem Biol & Environm, Yuxi 653100, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2021年 / 23卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Synthesis; benzophenone; antitumor; antioxidant; computational chemistry;

D O I：

10.1080/10286020.2020.1856096

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five polyhydroxybenzophenones were synthesized, then their antitumor and antioxidant activities were evaluated. Compounds 1-3 and 5 exhibited obvious antitumor activity. Among them, compounds 1 and 2 exhibited stronger cytotoxicity against hepatocarcinoma SMMC-7721 cells than cisplatin, with half maximal inhibitory concentrations (IC50) of approximately 3.86 and 5.32 mu M, respectively. Compounds 1, 2, and 3 exhibited stronger antioxidant activity than trolox, with IC50 values of 11.15, 10.15, and 8.91 mu M, respectively, and the antioxidant mechanism and strength of all compounds were further verified using computational chemistry. These results demonstrated that compounds 1-3 and 5 were very promising leads for further structural modification.

引用

页码：1171 / 1181

页数：11

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