Suberin Fatty Acids from Outer Birch Bark: Isolation and Physical Material Characterization

被引:19
|
作者
Heinamaki, Jyrki [1 ]
Pirttimaa, Minni M. [2 ]
Alakurtti, Sami [2 ]
Pitkanen, H. Pauliina [2 ]
Kanerva, Heimo [2 ]
Hulkko, Janne [2 ]
Paaver, Urve [1 ]
Aruvali, Jaan [3 ]
Yliruusi, Jouko [4 ]
Kogermann, Karin [1 ]
机构
[1] Univ Tartu, Fac Med, Inst Pharm, Nooruse 1, EE-50411 Tartu, Estonia
[2] VTT Tech Res Ctr Finland Ltd, VTT Ind Synth, Biologinkuja 7,POB 1000, FI-02044 Espoo, Finland
[3] Univ Tartu, Inst Ecol & Earth Sci, Dept Geog, Ravila 14A, EE-50411 Tartu, Estonia
[4] Univ Helsinki, Fac Pharm, Div Pharmaceut Chem & Technol, POB 56,Viikinkaari 5E, FI-00014 Helsinki, Finland
来源
JOURNAL OF NATURAL PRODUCTS | 2017年 / 80卷 / 04期
关键词
BIOPOLYESTER; PLANTS; CUTIN; SKIN;
D O I
10.1021/acs.jnatprod.6b00771
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
The isolation and physical material properties of suberin fatty acids (SFAs) were investigated with special reference to their potential applications as novel pharmaceutical excipients. SFAs were isolated from outer birch bark (OBB) with a new extractive hydrolysis method. The present simplified isolation process resulted in a moderate batch yield and chemical purity of SFAs, but further development is needed for establishing batch-to-batch variation. Cryogenic milling was the method of choice for the particle size reduction of SFAs powder. The cryogenically milled SFAs powder exhibited a semicrystalline structure with apparent microcrystalline domains within an amorphous fatty acids matrix. The thermogravirrietric analysis (TGA) of SFAs samples showed a good thermal stability up to 200 degrees C, followed by a progressive weight loss, reaching a plateau at about 95% volatilization at about 470 degrees C. The binary blends of SFAs and microcrystalline cellulose (MCC; Avicel PH 101) in a ratio of 25:75 (w/w) displayed good powder flow and tablet compression properties. The corresponding theophylline-containing tablets showed sustained or prolonged-release characteristics. The physicochemical and bulk powder properties of SFAs isolated from OBB are auspicious in terms of potential pharmaceutical excipient applications.
引用
收藏
页码:916 / 924
页数:9
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