Effect of intravitreal conbercept treatment before vitrectomy in proliferative diabetic retinopathy

被引:16
作者
Mao, Jian-Bo [1 ]
Wu, Han-Fei [1 ]
Chen, Yi-Qi [1 ]
Zhao, Shi-Xin [1 ]
Tao, Ji-Wei [1 ]
Zhang, Yun [1 ]
Zheng, Bin [1 ]
Wang, Lin [2 ]
Shen, Li-Jun [1 ]
机构
[1] Wenzhou Med Univ, Dept Retina Ctr, Affiliated Eye Hosp, Hangzhou 310000, Zhejiang, Peoples R China
[2] Binzhou Med Univ, Affiliated Hosp, Binzhou 256600, Shandong, Peoples R China
关键词
conbercept; proliferative diabetic retinopathy; vitrectomy; BEVACIZUMAB; THERAPY; ANGIOGENESIS; EFFICACY; ADJUVANT; SURGERY; SAFETY; EYES;
D O I
10.18240/ijo.2018.07.23
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
AIM: To evaluate the safety and efficacy of intravitreal conbercept (IVC) injections as pretreatment for pars plana vitrectomy (PPV) in severe proliferative diabetic retinopathy(PDR). METHODS: This was a retrospective chart review of all patients who underwent PPV for PDR from January 2014 to October 2016. Patients who underwent IVC injection before PPV were assigned to the IVC group; the others were assigned to the control group. The IVC was performed 3-7d before surgery in the IVC group. All the eyes in the two groups were operated by the same doctor to complete the vitrectomy. Intraoperative complications and the changes in best-corrected visual acuity (BCVA) before and after surgery were compared between the two groups. RESULTS: A total of 68 eyes of 63 patients (22 eyes in the IVC group and 46 eyes in the control group) were examined. The risk of intraoperative bleeding was lower in the IVC group (2/22) than in the control group (25/46, P=0.000). Furthermore, the use of endodiathermy was significantly lower in the IVC group (1/22) than in the control group (12/46, P=0.047). The surgical time in the IVC group (112.64 +/- 34.52min) was significantly shorter than in the control group (132.85 +/- 40.04min, P<0.05). Compared to the BCVA before surgery, the mean BCVA was significantly improved after surgery for both groups (P<0.05). CONCLUSION: PPV is an effective treatment and can improve vision in patients with PDR. Preoperative intravitreal injection of conbercept could reduce the chances of intraoperative bleeding and the use of endodiathermy and shorten the operative time, which are beneficial in the management of PDR.
引用
收藏
页码:1217 / 1221
页数:5
相关论文
共 24 条
  • [1] Changes in retinal neovascularization after pegaptanib (Macugen) therapy in diabetic individuals
    Adamis, AP
    Altaweel, M
    Bressler, NM
    Cunningham, ET
    Davis, MD
    Goldbaum, M
    Gonzales, C
    Guyer, DR
    Katz, B
    Patel, M
    [J]. OPHTHALMOLOGY, 2006, 113 (01) : 23 - 28
  • [2] The adjunctive use of pre-operative intravitreal bevacizumab in the setting of proliferative diabetic retinopathy
    Al-Kharashi, Abdullah
    Galbinur, Tural
    Mandelcorn, Efrem D.
    Muni, Rajeev H.
    Nabavi, Mir
    Kertes, Peter J.
    [J]. SAUDI JOURNAL OF OPHTHALMOLOGY, 2016, 30 (04) : 217 - 220
  • [3] Cellular abnormalities of blood vessels as targets in cancer
    Baluk, P
    Hashizume, H
    McDonald, DM
    [J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 2005, 15 (01) : 102 - 111
  • [4] Du LP, 2015, MOL VIS, V21, P185
  • [5] Preoperative Intravitreal Bevacizumab Use as an Adjuvant to Diabetic Vitrectomy: Histopathologic Findings and Clinical Implications
    El-Sabagh, Hazem A.
    Abdelghaffar, Walid
    Labib, Ahmad M.
    Mateo, Carlos
    Hashem, Tarek M.
    Al-Tamimi, Dalal M.
    Selim, Abdulhafez A.
    [J]. OPHTHALMOLOGY, 2011, 118 (04) : 636 - 641
  • [6] Pars plana vitrectomy in vitreous hemorrhage with or without Intravitreal Bevacizumab: A comparative overview
    Faisal, Syed Muhammad
    Tahir, Muhammad Ali
    Cheema, Alyscia Miriam
    Anjum, Muhammad Ijaz
    [J]. PAKISTAN JOURNAL OF MEDICAL SCIENCES, 2018, 34 (01) : 221 - 225
  • [7] Opinion - Angiogenesis: an organizing principle for drug discovery?
    Folkman, Judah
    [J]. NATURE REVIEWS DRUG DISCOVERY, 2007, 6 (04) : 273 - 286
  • [8] FP3: A Novel VEGF Blocker with Anti-Angiogenic and Anti-Tumor Effects
    Gao, Weili
    Jin, Ketao
    Lan, Huanrong
    Han, Na
    Cao, Feilin
    Teng, Lisong
    [J]. HEPATO-GASTROENTEROLOGY, 2012, 59 (120) : 2543 - 2547
  • [9] Holladay JT, 1997, J REFRACT SURG, V13, P388
  • [10] Long-term Effects of Therapy with Ranibizumab on Diabetic Retinopathy Severity and Baseline Risk Factors for Worsening Retinopathy
    Ip, Michael S.
    Domalpally, Amitha
    Sun, Jennifer K.
    Ehrlich, Jason S.
    [J]. OPHTHALMOLOGY, 2015, 122 (02) : 367 - 374