The onset of pediatric refractory status epilepticus is not distributed uniformly during the day

被引：1

作者：

Sanchez Fernandez, Ivan ^{[1
,2
]}

Gainza-Lein, Marina ^{[1
,3
]}

Abend, Nicholas S. ^{[4
]}

Amengual-Gual, Marta ^{[1
,5
]}

Anderson, Anne ^{[6
]}

Arya, Ravindra ^{[7
]}

Brenton, J. Nicholas ^{[8
]}

Carpenter, Jessica L. ^{[9
]}

Chapman, Kevin E. ^{[10
,11
]}

Clark, Justice ^{[1
]}

Farias-Moeller, Raquel ^{[12
]}

Gaillard, William Davis ^{[9
]}

Glauser, Tracy A. ^{[7
]}

Goldstein, Joshua ^{[13
]}

Goodkin, Howard P. ^{[8
]}

Guerriero, Rejean M. ^{[14
]}

Hecox, Kurt ^{[12
]}

Jackson, Michele ^{[1
]}

Kapur, Kush ^{[1
]}

Kelley, Sarah A. ^{[15
]}

Kossoff, Eric H. W. ^{[15
]}

Lai, Yi-Chen ^{[6
]}

McDonough, Tiffani L. ^{[16
]}

Mikati, Mohamad A. ^{[17
]}

Morgan, Lindsey A. ^{[18
,19
,20
]}

Novotny, Edward J. ^{[18
,19
,20
]}

Ostendorf, Adam P. ^{[21
]}

Payne, Eric T. ^{[22
]}

Peariso, Katrina ^{[7
]}

Piantino, Juan ^{[23
]}

Riviello, James J., Jr. ^{[6
]}

Sannagowdara, Kumar ^{[12
]}

Stafstrom, Carl E. ^{[15
]}

Tasker, Robert C. ^{[24
]}

Tchapyjnikov, Dmitry ^{[17
]}

Topjian, Alexis A. ^{[25
]}

Vasquez, Alejandra ^{[1
]}

Wainwright, Mark S. ^{[18
,19
,20
]}

Wilfong, Angus ^{[26
]}

Williams, Korwyn ^{[26
]}

Loddenkemper, Tobias ^{[1
]}

机构：

[1] Harvard Med Sch, Boston Childrens Hosp, Dept Neurol, Div Epilepsy & Clin Neurophysiol, Boston, MA 02115 USA

[2] Univ Barcelona, Hosp St Joan Deu, Dept Child Neurol, Barcelona, Spain

[3] Univ Austral Chile, Fac Med, Valdivia, Chile

[4] Univ Penn, Perelman Sch Med, Childrens Hosp Philadelphia, Div Neurol, Philadelphia, PA 19104 USA

[5] Univ Illes Balears, Hosp Univ Son Espases, Dept Pediat, Pediat Neurol Unit, Palma De Mallorca, Spain

[6] Texas Childrens Hosp, Baylor Coll Med, Dept Pediat, Sect Neurol & Dev Neurosci, Houston, TX 77030 USA

[7] Univ Cincinnati, Coll Med, Div Pediat Neurol, Cincinnati Childrens Hosp,Med Ctr,Dept Pediat, Cincinnati, OH USA

[8] Univ Virginia Hlth Syst, Dept Neurol & Pediat, Charlottesville, VA USA

[9] George Washington Univ, Sch Med & Hlth Sci, Childrens Natl Med Ctr, Ctr Neurosci, Washington, DC 20052 USA

[10] Univ Colorado, Sch Med, Childrens Hosp Colorado, Dept Pediat, Aurora, CO USA

[11] Univ Colorado, Sch Med, Childrens Hosp Colorado, Dept Neurol, Aurora, CO USA

[12] Med Coll Wisconsin, Childrens Hosp Wisconsin, Dept Pediat Neurol, Milwaukee, WI 53226 USA

[13] Northwestern Univ, Feinberg Sch Med, Ruth D & Ken M Davee Pediat Neurocrit Care Progra, Chicago, IL 60611 USA

[14] Washington Univ, Sch Med, Dept Neurol, Div Pediat & Dev Neurol, St Louis, MO 63110 USA

[15] Johns Hopkins Univ, Johns Hopkins Hosp, Dept Neurol, Baltimore, MD USA

[16] Columbia Univ, Med Ctr, Dept Neurol, Div Child Neurol, New York, NY USA

[17] Duke Univ, Med Ctr, Div Pediat Neurol, Durham, NC USA

[18] Univ Washington, Dept Pediat, Seattle Childrens Hosp, Seattle, WA 98195 USA

[19] Univ Washington, Dept Neurol, Seattle Childrens Hosp, Seattle, WA 98195 USA

[20] Seattle Childrens Res Inst, Ctr Integrat Brain Res, Seattle, WA USA

[21] Ohio State Univ, Dept Neurol, Nationwide Childrens Hosp, Columbus, OH 43210 USA

[22] Mayo Clin, Sch Med, Dept Neurol, Rochester, MN USA

[23] Oregon Hlth & Sci Univ, Dept Neurol, Doernbercher Childrens Hosp, Portland, OR 97201 USA

[24] Harvard Med Sch, Boston Childrens Hosp, Dept Anesthesiol Crit Care & Pain Med, Dept Neurol, Boston, MA 02115 USA

[25] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Div Crit Care Med, Philadelphia, PA 19104 USA

[26] Univ Arizona, Sch Med, Dept Pediat, Barrow Neurol Inst,Phoenix Childrens Hosp, Phoenix, AZ USA

来源：

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY | 2019年 / 70卷

关键词：

24-hour rhythms; Chronobiology; Epilepsy; Pediatric; Status epilepticus; CONVULSIVE STATUS EPILEPTICUS; TEMPORAL DISTRIBUTION; SEIZURES; PATTERNS; MORTALITY; TIME;

D O I：

10.1016/j.seizure.2019.06.017

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Purpose: To evaluate whether the onset of pediatric refractory status epilepticus (rSE) is related to time of day. Method: We analyzed the time of day for the onset of rSE in this prospective observational study performed from June 2011 to May 2019 in pediatric patients (1 month to 21 years of age). We evaluated the temporal distribution of pediatric rSE utilizing a cosinor analysis. We calculated the midline estimating statistic of rhythm (MESOR) and amplitude. MESOR is the estimated mean number of rSE episodes per hour if they were evenly distributed. Amplitude is the difference between MESOR and maximum rSE episodes/hour, or between MESOR and minimum rSE episodes/hour. We also evaluated the temporal distribution of time to treatment. Results: We analyzed 368 patients (58% males) with a median (p(25) - p(75)) age of 4.2 (1.3-9.7) years. The MESOR was 15.3 (95% CI: 13.9-16.8) and the amplitude was 3.2 (95% CI: 1.1-5.3), p = 0.0024, demonstrating that the distribution is not uniform, but better described as varying throughout the day with a peak in the morning (11am-12 pm) and trough at night (11 pm-12 am). The duration from rSE onset to application of the first non-benzodiazepine antiseizure medication peaked during the early morning (2am-3 am) with a minimum during the afternoon (2 pm-3 pm) (p = 0.0179). Conclusions: The distribution of rSE onset is not uniform during the day. rSE onset shows a 24-h distribution with a peak in the mid-morning (11am-12pm) and a trough at night (11 pm-12am).

引用

页码：90 / 96

页数：7

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